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10.3892/ijmm.2017.2870 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.2870 C5360392!5360392!28204821     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2017 ; 39 (3): 549-58 Nephropedia Template TP {{tp|p=28204821|t=2017. Neutrophil extracellular traps induce IL-1? production by macrophages in combination with lipopolysaccharide |pdf=|usr=}}{{28204821}} gab.com Text Neutrophil extracellular traps induce IL-1 production by macrophages in combination with lipopolysaccharide JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28204821 #FOAvip Upon exposure to invading microorganisms, neutrophils undergo NETosis, a recently identified type of programmed cell death, and release neutrophil extracellular traps (NETs). NETs are described as an antimicrobial mechanism, based on the fact that NETs can trap microorganisms and exhibit bactericidal activity through the action of NET-associated components. In contrast, the components of NETs have been recognized as damage-associated molecular pattern molecules (DAMPs), which trigger inflammatory signals to induce cell death, inflammation and organ failure. In the present study, to clarify the effect of NETs on cytokine production by macrophages, mouse macrophage-like J774 cells were treated with NETs in combination with lipopolysaccharide (LPS) as a constituent of pathogen-associated molecular patterns. The results revealed that NETs significantly induced the production of interleukin (IL)-1? by J774 cells in the presence of LPS. Notably, the NET/LPS-induced IL-1? production was inhibited by both caspase-1 and caspase-8 inhibitors. Furthermore, nucleases and serine protease inhibitors but not anti-histone antibodies significantly inhibited the NET/LPS-induced IL-1? production. Moreover, we confirmed that caspase-1 and caspase-8 were activated by NETs/LPS, and the combination of LPS, DNA and neutrophil elastase induced IL-1? production in reconstitution experiments. These observations indicate that NETs induce the production of IL-1? by J774 macrophages in combination with LPS via the caspase-1 and caspase-8 pathways, and NET-associated DNA and serine proteases are involved in NET/LPS-induced IL-1? production as essential components. Twit Text FOAVip Neutrophil extracellular traps induce IL-1 production by macrophages in combination with lipopolysaccharide ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28204821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28204821 #FOAvip English Wikipedia <ref>{{Cite pmid|28204821}}</ref> Neutrophil extracellular traps induce IL-1? production by macrophages in combination with lipopolysaccharide #MMPMID28204821 Hu Z; Murakami T; Tamura H; Reich J; Kuwahara-Arai K; Iba T; Tabe Y; Nagaoka I Int J Mol Med 2017[Mar]; 39 (3): 549-58 PMID28204821show ga Upon exposure to invading microorganisms, neutrophils undergo NETosis, a recently identified type of programmed cell death, and release neutrophil extracellular traps (NETs). NETs are described as an antimicrobial mechanism, based on the fact that NETs can trap microorganisms and exhibit bactericidal activity through the action of NET-associated components. In contrast, the components of NETs have been recognized as damage-associated molecular pattern molecules (DAMPs), which trigger inflammatory signals to induce cell death, inflammation and organ failure. In the present study, to clarify the effect of NETs on cytokine production by macrophages, mouse macrophage-like J774 cells were treated with NETs in combination with lipopolysaccharide (LPS) as a constituent of pathogen-associated molecular patterns. The results revealed that NETs significantly induced the production of interleukin (IL)-1? by J774 cells in the presence of LPS. Notably, the NET/LPS-induced IL-1? production was inhibited by both caspase-1 and caspase-8 inhibitors. Furthermore, nucleases and serine protease inhibitors but not anti-histone antibodies significantly inhibited the NET/LPS-induced IL-1? production. Moreover, we confirmed that caspase-1 and caspase-8 were activated by NETs/LPS, and the combination of LPS, DNA and neutrophil elastase induced IL-1? production in reconstitution experiments. These observations indicate that NETs induce the production of IL-1? by J774 macrophages in combination with LPS via the caspase-1 and caspase-8 pathways, and NET-associated DNA and serine proteases are involved in NET/LPS-induced IL-1? production as essential components. äNeutrophil extracellular traps induce IL-1? production by macrophages (epmc).pdf DeepDyve Pubget Overpricing