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Characterization of BAFF and APRIL subfamily receptors in rainbow trout
(Oncorhynchus mykiss) Potential role of the BAFF / APRIL axis in the
pathogenesis of proliferative kidney disease
#MMPMID28323891
Granja AG
; Holland JW
; Pignatelli J
; Secombes CJ
; Tafalla C
PLoS One
2017[]; 12
(3
): e0174249
PMID28323891
show ga
Proliferative kidney disease (PKD) is a parasitic infection of salmonid fish
characterized by hyper-secretion of immunoglobulins in response to the presence
of the myxozoan parasite, Tetracapsuloides bryosalmonae. In this context, we
hypothesized that the BAFF/APRIL axis, known to play a major role in B cell
differentiation and survival in mammals, could be affected by the parasite and
consequently be involved in the apparent shift in normal B cell activity. To
regulate B cell activity, BAFF and APRIL bind to transmembrane activator and
calcium modulator and cyclophilin ligand interactor (TACI) and B cell maturation
antigen (BCMA), whereas BAFF also binds to BAFF receptor (BAFF-R). In teleost
fish, although some BAFF and APRIL sequences have been reported, their receptors
have not been identified. Thus, as a first step in the current work, we have
identified homologues to mammalian TACI, BCMA and BAFF-R in rainbow trout
(Oncorhynchus mykiss), that constitute the first report of BAFF and APRIL
receptor sequences in fish. Subsequently we studied the transcriptional
modulation of BAFF, APRIL, and the fish-specific related cytokine, BALM and their
putative receptors in fish naturally exposed to T. bryosalmonae. Finally, to gain
further insights on the functional role that these cytokines play during the
course of PKD, we have studied their effect on the survival of kidney IgM+ B
cells and on immunoglobulin transcription. Our results support the premise that
the BAFF / APRIL axis could play an important role during PKD, which may open the
possibility of new therapeutic treatments against the disease.
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