Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.2337/db16-1199 http://scihub22266oqcxt.onion/10.2337/db16-1199 C5360301!5360301!28082458     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes 2017 ; 66 (4): 994-1007 Nephropedia Template TP {{tp|p=28082458|t=2017. Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes |pdf=|usr=}}{{28082458}} gab.com Text Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=28082458 #FOAvip Islet inflammation promotes ?-cell loss and type 2 diabetes (T2D), a process replicated in Zucker Diabetic Fatty (ZDF) rats in which ?-cell loss has been linked to cannabinoid-1 receptor (CB1R)?induced proinflammatory signaling in macrophages infiltrating pancreatic islets. Here, we analyzed CB1R signaling in macrophages and its developmental role in T2D. ZDF rats with global deletion of CB1R are protected from ?-cell loss, hyperglycemia, and nephropathy that are present in ZDF littermates. Adoptive transfer of CB1R?/? bone marrow to ZDF rats also prevents ?-cell loss and hyperglycemia but not nephropathy. ZDF islets contain elevated levels of CB1R, interleukin-1?, tumor necrosis factor-?, the chemokine CCL2, and interferon regulatory factor-5 (IRF5), a marker of inflammatory macrophage polarization. In primary cultured rodent and human macrophages, CB1R activation increased Irf5 expression, whereas knockdown of Irf5 blunted CB1R-induced secretion of inflammatory cytokines without affecting CCL2 expression, which was p38MAPK? dependent. Macrophage-specific in vivo knockdown of Irf5 protected ZDF rats from ?-cell loss and hyperglycemia. Thus, IRF5 is a crucial downstream mediator of diabetogenic CB1R signaling in macrophages and a potential therapeutic target. Twit Text FOAVip Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=28082458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28082458 #FOAvip English Wikipedia <ref>{{Cite pmid|28082458}}</ref> Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes #MMPMID28082458 Jourdan T; Szanda G; Cinar R; Godlewski G; Holovac DJ; Park JK; Nicoloro S; Shen Y; Liu J; Rosenberg AZ; Liu Z; Czech MP; Kunos G Diabetes 2017[Apr]; 66 (4): 994-1007 PMID28082458show ga Islet inflammation promotes ?-cell loss and type 2 diabetes (T2D), a process replicated in Zucker Diabetic Fatty (ZDF) rats in which ?-cell loss has been linked to cannabinoid-1 receptor (CB1R)?induced proinflammatory signaling in macrophages infiltrating pancreatic islets. Here, we analyzed CB1R signaling in macrophages and its developmental role in T2D. ZDF rats with global deletion of CB1R are protected from ?-cell loss, hyperglycemia, and nephropathy that are present in ZDF littermates. Adoptive transfer of CB1R?/? bone marrow to ZDF rats also prevents ?-cell loss and hyperglycemia but not nephropathy. ZDF islets contain elevated levels of CB1R, interleukin-1?, tumor necrosis factor-?, the chemokine CCL2, and interferon regulatory factor-5 (IRF5), a marker of inflammatory macrophage polarization. In primary cultured rodent and human macrophages, CB1R activation increased Irf5 expression, whereas knockdown of Irf5 blunted CB1R-induced secretion of inflammatory cytokines without affecting CCL2 expression, which was p38MAPK? dependent. Macrophage-specific in vivo knockdown of Irf5 protected ZDF rats from ?-cell loss and hyperglycemia. Thus, IRF5 is a crucial downstream mediator of diabetogenic CB1R signaling in macrophages and a potential therapeutic target. äDevelopmental Role of Macrophage Cannabinoid-1 Receptor Signaling in T(epmc).pdf DeepDyve Pubget Overpricing