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10.1016/j.bbalip.2016.09.022 http://scihub22266oqcxt.onion/10.1016/j.bbalip.2016.09.022 C5360178!5360178!27713004     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2017 ; 1862 (4): 407-15 Nephropedia Template TP {{tp|p=27713004|t=2017. Biological and pathophysiological roles of end-products of DHA oxidation |pdf=|usr=}}{{27713004}} gab.com Text Biological and pathophysiological roles of end-products of DHA oxidation JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27713004 #FOAvip Background: Polyunsaturated fatty acids (PUFA) are known to be present and/or enriched in vegetable and fish oils. Among fatty acids, n-3 PUFA are generally considered to be protective in inflammation-related diseases. The guidelines for substituting saturated fatty acids for PUFAs have been highly publicized for decades by numerous health organizations. Recently, however, the beneficial properties of n-3 PUFA are questioned by detailed analyses of multiple randomized controlled clinical trials. The reported heterogeneity of results is likely due not only to differential effects of PUFAs on various pathological processes in humans, but also to the wide spectrum of PUFA's derived products generated in vivo. Scope of review: The goal of this review is to discuss the studies focused on well-defined end-products of PUFAs oxidation, their generation, presence in various pathological and physiological conditions, their biological activities and known receptors. Carboxyethylpyrrole (CEP), a DHA-derived oxidized product, is especially emphasized due to recent data demonstrating its pathophysiological significance in many inflammation-associated diseases, including atherosclerosis, hyperlipidemia, thrombosis, macular degeneration, and tumor progression. Major conclusions: CEP is a product of radical-based oxidation of PUFA that forms adducts with proteins and lipids in blood and tissues, generating new powerful ligands for TLRs and scavenger receptors. The interaction of CEP with these receptors affects inflammatory response, angiogenesis, and wound healing. General Significance: The detailed understanding of CEP?mediated cellular responses may provide a basis for the development of novel therapeutic strategies and dietary recommendations. Twit Text FOAVip Biological and pathophysiological roles of end-products of DHA oxidation ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27713004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27713004 #FOAvip English Wikipedia <ref>{{Cite pmid|27713004}}</ref> Biological and pathophysiological roles of end-products of DHA oxidation #MMPMID27713004 Yakubenko VP; Byzova TV Biochim Biophys Acta 2017[Apr]; 1862 (4): 407-15 PMID27713004show ga Background: Polyunsaturated fatty acids (PUFA) are known to be present and/or enriched in vegetable and fish oils. Among fatty acids, n-3 PUFA are generally considered to be protective in inflammation-related diseases. The guidelines for substituting saturated fatty acids for PUFAs have been highly publicized for decades by numerous health organizations. Recently, however, the beneficial properties of n-3 PUFA are questioned by detailed analyses of multiple randomized controlled clinical trials. The reported heterogeneity of results is likely due not only to differential effects of PUFAs on various pathological processes in humans, but also to the wide spectrum of PUFA's derived products generated in vivo. Scope of review: The goal of this review is to discuss the studies focused on well-defined end-products of PUFAs oxidation, their generation, presence in various pathological and physiological conditions, their biological activities and known receptors. Carboxyethylpyrrole (CEP), a DHA-derived oxidized product, is especially emphasized due to recent data demonstrating its pathophysiological significance in many inflammation-associated diseases, including atherosclerosis, hyperlipidemia, thrombosis, macular degeneration, and tumor progression. Major conclusions: CEP is a product of radical-based oxidation of PUFA that forms adducts with proteins and lipids in blood and tissues, generating new powerful ligands for TLRs and scavenger receptors. The interaction of CEP with these receptors affects inflammatory response, angiogenesis, and wound healing. General Significance: The detailed understanding of CEP?mediated cellular responses may provide a basis for the development of novel therapeutic strategies and dietary recommendations. äBiological and pathophysiological roles of end-products of DHA oxidati(epmc).pdf DeepDyve Pubget Overpricing