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10.1186/s40425-017-0230-9 http://scihub22266oqcxt.onion/10.1186/s40425-017-0230-9 C5359946!5359946 !28331617     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28331617 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunother+Cancer 2017 ; 5 (ä): 28 Nephropedia Template TP {{tp|p=28331617 |t=2017. Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment |pdf=|usr=}}{{28331617 }} gab.com Text Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment JO: J Immunother Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28331617 #FOAvip Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches. Twit Text FOAVip Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment ????J Immunother Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28331617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28331617 #FOAvip English Wikipedia <ref>{{Cite pmid|28331617 }}</ref> Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment #MMPMID28331617 Scarfò I ; Maus MV J Immunother Cancer 2017[]; 5 (ä): 28 PMID28331617 show ga Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches. |Animals [MESH] |Humans [MESH] |Mice [MESH] |Neoplasms/*drug therapy/immunology/pathology [MESH] |Receptors, Antigen, T-Cell/*immunology [MESH] |T-Lymphocytes/immunology/pathology [MESH]Current approaches to increase CAR T cell potency in solid tumors: tar(epmc).pdf DeepDyve Pubget Overpricing