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2017 ; 18
(1
): 177
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gab.com Text
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English Wikipedia
NaviGO: interactive tool for visualization and functional similarity and
coherence analysis with gene ontology
#MMPMID28320317
Wei Q
; Khan IK
; Ding Z
; Yerneni S
; Kihara D
BMC Bioinformatics
2017[Mar]; 18
(1
): 177
PMID28320317
show ga
BACKGROUND: The number of genomics and proteomics experiments is growing rapidly,
producing an ever-increasing amount of data that are awaiting functional
interpretation. A number of function prediction algorithms were developed and
improved to enable fast and automatic function annotation. With the well-defined
structure and manual curation, Gene Ontology (GO) is the most frequently used
vocabulary for representing gene functions. To understand relationship and
similarity between GO annotations of genes, it is important to have a convenient
pipeline that quantifies and visualizes the GO function analyses in a systematic
fashion. RESULTS: NaviGO is a web-based tool for interactive visualization,
retrieval, and computation of functional similarity and associations of GO terms
and genes. Similarity of GO terms and gene functions is quantified with six
different scores including protein-protein interaction and context based
association scores we have developed in our previous works. Interactive
navigation of the GO function space provides intuitive and effective real-time
visualization of functional groupings of GO terms and genes as well as
statistical analysis of enriched functions. CONCLUSIONS: We developed NaviGO,
which visualizes and analyses functional similarity and associations of GO terms
and genes. The NaviGO webserver is freely available at:
http://kiharalab.org/web/navigo .