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Evaluation of Renal Function in Pregnant Women with Malaria: A Case-Control Study
in a Mesoendemic Area
#MMPMID28367218
Afrifa J
; Essien-Baidoo S
; Baffour Gyau A
; Ephraim RK
Obstet Gynecol Int
2017[]; 2017
(?): 6030943
PMID28367218
show ga
Background. Malaria is known to have devastating effects on mortality in tropical
and subtropical regions with the effect being magnified in people with weakened
immunity such as those in pregnancy. We assessed the effect of malaria on renal
function of pregnant women receiving antenatal care in a mesoendemic area of
Ghana. Methodology. A case-control study that enrolled a total of 100 pregnant
women (50 with confirmed gestational malaria as cases and 50 without malaria as
controls). Sociodemographic characteristics, obstetric history (obtained with a
questionnaire), urea, creatinine, sodium, and potassium were analyzed using a
chemistry automated analyzer. Results. Plasma urea and creatinine were
significantly increased (P = 0.0003 and P < 0.0001, resp.) among cases compared
to the controls. Also the levels of urea (P = 0.033), creatinine (P = 0.032), and
parasitaemia (0.016) were significantly increased with increasing gestational
age. Conclusion. Malaria has a significant impact on renal function (most
importantly, urea and creatinine) and is also significantly associated with
increasing gestational age among our study participants.
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