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10.1038/celldisc.2017.6 http://scihub22266oqcxt.onion/10.1038/celldisc.2017.6 C5359216!5359216!28373913     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Discov 2017 ; 3 (ä): 17006- Nephropedia Template TP {{tp|p=28373913|t=2017. Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro |pdf=|usr=}}{{28373913}} gab.com Text Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro JO: Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=28373913 #FOAvip Type I interferon (IFN) serves as the first line of defense against invading pathogens. Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV to evade antiviral responses from host cells. Here we demonstrate that ZIKV nonstructural proteins NS1, NS4B and NS2B3 inhibit the induction of IFN and downstream IFN-stimulated genes through diverse strategies. NS1 and NS4B of ZIKV inhibit IFN? signaling at TANK-binding kinase 1 level, whereas NS2B-NS3 of ZIKV impairs JAK?STAT signaling pathway by degrading Jak1 and reduces virus-induced apoptotic cell death. Furthermore, co-operation of NS1, NS4B and NS2B3 further enhances viral infection by blocking IFN-induced autophagic degradation of NS2B3. Hence, our study reveals a novel antagonistic system employing multiple ZIKV nonstructural proteins in restricting the innate antiviral responses. Twit Text FOAVip Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro ????Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=28373913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28373913 #FOAvip English Wikipedia <ref>{{Cite pmid|28373913}}</ref> Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro #MMPMID28373913 Wu Y; Liu Q; Zhou J; Xie W; Chen C; Wang Z; Yang H; Cui J Cell Discov 2017[]; 3 (ä): 17006- PMID28373913show ga Type I interferon (IFN) serves as the first line of defense against invading pathogens. Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV to evade antiviral responses from host cells. Here we demonstrate that ZIKV nonstructural proteins NS1, NS4B and NS2B3 inhibit the induction of IFN and downstream IFN-stimulated genes through diverse strategies. NS1 and NS4B of ZIKV inhibit IFN? signaling at TANK-binding kinase 1 level, whereas NS2B-NS3 of ZIKV impairs JAK?STAT signaling pathway by degrading Jak1 and reduces virus-induced apoptotic cell death. Furthermore, co-operation of NS1, NS4B and NS2B3 further enhances viral infection by blocking IFN-induced autophagic degradation of NS2B3. Hence, our study reveals a novel antagonistic system employing multiple ZIKV nonstructural proteins in restricting the innate antiviral responses. äZika virus evades interferon-mediated antiviral response through the c(epmc).pdf DeepDyve Pubget Overpricing