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10.1007/s13238-017-0373-y http://scihub22266oqcxt.onion/10.1007/s13238-017-0373-y C5359186!5359186!28190217     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Protein+Cell 2017 ; 8 (4): 273-83 Nephropedia Template TP {{tp|p=28190217|t=2017. Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury |pdf=|usr=}}{{28190217}} gab.com Text Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=28190217 #FOAvip Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug cocktails robustly promoting in vitro cell reprogramming. We then administrated the drug cocktails to mice with acute liver injuries induced by partial hepatectomy or toxic treatment. Our results demonstrated that the drug cocktails which promoted cell reprogramming in vitro improved liver regeneration and hepatic function in vivo after acute injuries. The underlying mechanism could be that expression of pluripotent genes activated after injury is further upregulated by drug cocktails. Thus our study offers proof-of-concept evidence that cocktail of clinical compounds improving cell reprogramming favors tissue recovery after acute damages, which is an attractive strategy for regenerative purpose.Electronic supplementary material: The online version of this article (doi:10.1007/s13238-017-0373-y) contains supplementary material, which is available to authorized users. Twit Text FOAVip Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=28190217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28190217 #FOAvip English Wikipedia <ref>{{Cite pmid|28190217}}</ref> Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury #MMPMID28190217 Tang Y; Cheng L Protein Cell 2017[Apr]; 8 (4): 273-83 PMID28190217show ga Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug cocktails robustly promoting in vitro cell reprogramming. We then administrated the drug cocktails to mice with acute liver injuries induced by partial hepatectomy or toxic treatment. Our results demonstrated that the drug cocktails which promoted cell reprogramming in vitro improved liver regeneration and hepatic function in vivo after acute injuries. The underlying mechanism could be that expression of pluripotent genes activated after injury is further upregulated by drug cocktails. Thus our study offers proof-of-concept evidence that cocktail of clinical compounds improving cell reprogramming favors tissue recovery after acute damages, which is an attractive strategy for regenerative purpose.Electronic supplementary material: The online version of this article (doi:10.1007/s13238-017-0373-y) contains supplementary material, which is available to authorized users. äCocktail of chemical compounds robustly promoting cell reprogramming p(epmc).pdf DeepDyve Pubget Overpricing