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10.2147/COPD.S115969 http://scihub22266oqcxt.onion/10.2147/COPD.S115969 C5359000!5359000 !28352169     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28352169 &cmd=llinks): Failed to open stream: HTTP request failed! 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Evidence of eosinophil extracellular trap cell death in COPD: does it represent the trigger that switches on the disease? |pdf=|usr=}}{{28352169 }} gab.com Text Evidence of eosinophil extracellular trap cell death in COPD: does it represent the trigger that switches on the disease JO: Int J Chron Obstruct Pulmon Dis http://www.kidney.de/pget.php?&tw=1&pmid=28352169 #FOAvip In spite of the numerous studies on chronic obstructive pulmonary disease (COPD), the cellular and molecular basis of the disease's development remain unclear. Neutrophils and eosinophils are known to be key players in COPD. Recently, neutrophil extracellular trap cell death (NETosis), a mechanism due to decondensation and extrusion of chromatin to form extracellular traps, has been demonstrated in COPD. However, there is limited knowledge about eosinophil extracellular trap cell death (EETosis) and its role in the pathogenesis of COPD. The aim of this study was to evaluate EETosis in stable COPD. Induced sputum obtained from healthy smokers and low exacerbation risk COPD A or B group patients or high exacerbation risk COPD C or D group patients were included. Samples were examined using electron microscopy and immunofluorescence. Healthy smokers (n=10) and COPD A (n=19) group exhibited neutrophilic or paucigranulocytic phenotypes, with NETosis being absent in these patients. In contrast, COPD B (n=29), with eosinophilic or mixed phenotypes, showed EETosis and incipient NETosis. COPD C (n=18) and COPD D groups (n=13) were differentiated from low exacerbation rate-COPD group by the abundant cellular debris, with COPD C group having an eosinophilic pattern and numerous cells undergoing EETosis. A hallmark of this group was the abundant released membranes that often appeared phagocytosed by neutrophils, which coincidentally exhibited early NETosis changes. The COPD D group included patients with a neutrophilic or mixed pattern, with abundant neutrophil extracellular trap-derived material. This study is the first to demonstrate EETosis at different stages of stable COPD. The results suggest a role for eosinophils in COPD pathophysiology, especially at the beginning and during the persistence of the disease, regardless of whether the patient quit smoking, with EETosis debris probably triggering uncontrolled NETosis. The main target of these findings should be young smokers with the potential to develop COPD. Twit Text FOAVip Evidence of eosinophil extracellular trap cell death in COPD: does it represent the trigger that switches on the disease ????Int J Chron Obstruct Pulmon Dis http://www.kidney.de/pget.php?&tw=1&pmid=28352169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28352169 #FOAvip English Wikipedia <ref>{{Cite pmid|28352169 }}</ref> Evidence of eosinophil extracellular trap cell death in COPD: does it represent the trigger that switches on the disease? #MMPMID28352169 Uribe Echevarría L ; Leimgruber C ; García González J ; Nevado A ; Álvarez R ; García LN ; Quintar AA ; Maldonado CA Int J Chron Obstruct Pulmon Dis 2017[]; 12 (ä): 885-896 PMID28352169 show ga In spite of the numerous studies on chronic obstructive pulmonary disease (COPD), the cellular and molecular basis of the disease's development remain unclear. Neutrophils and eosinophils are known to be key players in COPD. Recently, neutrophil extracellular trap cell death (NETosis), a mechanism due to decondensation and extrusion of chromatin to form extracellular traps, has been demonstrated in COPD. However, there is limited knowledge about eosinophil extracellular trap cell death (EETosis) and its role in the pathogenesis of COPD. The aim of this study was to evaluate EETosis in stable COPD. Induced sputum obtained from healthy smokers and low exacerbation risk COPD A or B group patients or high exacerbation risk COPD C or D group patients were included. Samples were examined using electron microscopy and immunofluorescence. Healthy smokers (n=10) and COPD A (n=19) group exhibited neutrophilic or paucigranulocytic phenotypes, with NETosis being absent in these patients. In contrast, COPD B (n=29), with eosinophilic or mixed phenotypes, showed EETosis and incipient NETosis. COPD C (n=18) and COPD D groups (n=13) were differentiated from low exacerbation rate-COPD group by the abundant cellular debris, with COPD C group having an eosinophilic pattern and numerous cells undergoing EETosis. A hallmark of this group was the abundant released membranes that often appeared phagocytosed by neutrophils, which coincidentally exhibited early NETosis changes. The COPD D group included patients with a neutrophilic or mixed pattern, with abundant neutrophil extracellular trap-derived material. This study is the first to demonstrate EETosis at different stages of stable COPD. The results suggest a role for eosinophils in COPD pathophysiology, especially at the beginning and during the persistence of the disease, regardless of whether the patient quit smoking, with EETosis debris probably triggering uncontrolled NETosis. The main target of these findings should be young smokers with the potential to develop COPD. |Case-Control Studies [MESH] |Cell Death [MESH] |Cross-Sectional Studies [MESH] |Eosinophils/metabolism/*ultrastructure [MESH] |Extracellular Traps/*metabolism [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Forced Expiratory Volume [MESH] |Humans [MESH] |Lung/metabolism/physiopathology/*ultrastructure [MESH] |Male [MESH] |Microscopy, Confocal [MESH] |Microscopy, Electron [MESH] |Middle Aged [MESH] |Neutrophils/metabolism/*ultrastructure [MESH] |Pulmonary Disease, Chronic Obstructive/metabolism/*pathology/physiopathology [MESH] |Smoking Cessation [MESH] |Smoking Prevention [MESH] |Smoking/adverse effects [MESH] |Sputum/cytology/metabolism [MESH]Evidence of eosinophil extracellular trap cell death in COPD: does it (epmc).pdf DeepDyve Pubget Overpricing