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10.3892/ijmm.2017.2853 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.2853 C5358695!5358695 !28075449     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28075449 &cmd=llinks): Failed to open stream: HTTP request failed! 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Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis |pdf=|usr=}}{{28075449 }} gab.com Text Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28075449 #FOAvip Myasthenia gravis (MG) is a rare debilitating autoimmune neuromuscular disorder. Many studies have focused on the mechanism and treatment strategies of MG. However, the exact pathogenesis of MG and effective treatment strategies remain unclear. Recent studies have indicated that microRNAs (miRNAs or miRs) can regulate the pathological pathways of MG, suggesting their potential role in novel treatments. In the present study, we created a comprehensive catalog of experimentally confirmed MG risk genes and miRNAs by manually mining published literature and public databases. Based on these genes and miRNAs, we identified 41 MG risk pathways and 105 approved drugs that can affect these pathways. Some important MG-related pathways, such as hsa04060 (cytokine-cytokine receptor interaction) and hsa05200 (pathway in cancer), were found to be regulated by MG risk miRNAs and drugs. Furthermore, we constructed an miRNA-regulated drug-pathway network and identified miRNAs and drugs that synergistically regulate key MG pathways and biological processes. We developed a drug repurposing strategy to identify 25 drug repurposing candidates for MG; several of these drugs, such as rituximab, adalimumab, sunitinib, and muromonab, have the potential to be novel MG treatment drugs. This study provides novel insight into the pathogenesis of MG and potential drug candidates for MG were identified. Twit Text FOAVip Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28075449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28075449 #FOAvip English Wikipedia <ref>{{Cite pmid|28075449 }}</ref> Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis #MMPMID28075449 Cao Y ; Lu X ; Wang J ; Zhang H ; Liu Z ; Xu S ; Wang T ; Ning S ; Xiao B ; Wang L Int J Mol Med 2017[Feb]; 39 (2 ): 268-278 PMID28075449 show ga Myasthenia gravis (MG) is a rare debilitating autoimmune neuromuscular disorder. Many studies have focused on the mechanism and treatment strategies of MG. However, the exact pathogenesis of MG and effective treatment strategies remain unclear. Recent studies have indicated that microRNAs (miRNAs or miRs) can regulate the pathological pathways of MG, suggesting their potential role in novel treatments. In the present study, we created a comprehensive catalog of experimentally confirmed MG risk genes and miRNAs by manually mining published literature and public databases. Based on these genes and miRNAs, we identified 41 MG risk pathways and 105 approved drugs that can affect these pathways. Some important MG-related pathways, such as hsa04060 (cytokine-cytokine receptor interaction) and hsa05200 (pathway in cancer), were found to be regulated by MG risk miRNAs and drugs. Furthermore, we constructed an miRNA-regulated drug-pathway network and identified miRNAs and drugs that synergistically regulate key MG pathways and biological processes. We developed a drug repurposing strategy to identify 25 drug repurposing candidates for MG; several of these drugs, such as rituximab, adalimumab, sunitinib, and muromonab, have the potential to be novel MG treatment drugs. This study provides novel insight into the pathogenesis of MG and potential drug candidates for MG were identified. |*Drug Discovery [MESH] |*Drug Repositioning [MESH] |Computational Biology/methods [MESH] |Databases, Nucleic Acid [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation/*drug effects [MESH] |Gene Regulatory Networks/*drug effects [MESH] |Humans [MESH] |MicroRNAs/*genetics [MESH] |Molecular Sequence Annotation [MESH] |Multigene Family [MESH] |Myasthenia Gravis/*drug therapy/*genetics/metabolism [MESH] |Signal Transduction/drug effects [MESH]Construction of an miRNA-regulated drug-pathway network reveals drug r(epmc).pdf DeepDyve Pubget Overpricing