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10.1172/jci.insight.90531 http://scihub22266oqcxt.onion/10.1172/jci.insight.90531 C5358489!5358489!28352659     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 2 (6): ä Nephropedia Template TP {{tp|p=28352659|t=ä. Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease |pdf=|usr=}}{{28352659}} gab.com Text Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28352659 #FOAvip Better identification of severe acute graft-versus-host disease (GvHD) may improve the outcome of this life-threatening complication of allogeneic hematopoietic stem cell transplantation. GvHD induces tissue damage and the release of damage-associated molecular pattern (DAMP) molecules. Here, we analyzed GvHD patients (n = 39) to show that serum heat shock protein glycoprotein 96 (Gp96) could be such a DAMP molecule. We demonstrate that serum Gp96 increases in gastrointestinal GvHD patients and its level correlates with disease severity. An increase in Gp96 serum level was also observed in a mouse model of acute GvHD. This model was used to identify complement C3 as a main partner of Gp96 in the serum. Our biolayer interferometry, yeast two-hybrid and in silico modeling data allowed us to determine that Gp96 binds to a complement C3 fragment encompassing amino acids 749?954, a functional complement C3 hot spot important for binding of different regulators. Accordingly, in vitro experiments with purified proteins demonstrate that Gp96 downregulates several complement C3 functions. Finally, experimental induction of GvHD in complement C3?deficient mice confirms the link between Gp96 and complement C3 in the serum and with the severity of the disease. Twit Text FOAVip Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28352659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28352659 #FOAvip English Wikipedia <ref>{{Cite pmid|28352659}}</ref> Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease #MMPMID28352659 Seignez A; Joly AL; Chaumonnot K; Hazoumé A; Sanka M; Marcion G; Boudesco C; Hammann A; Seigneuric R; Jégo G; Ducoroy P; Delarue P; Senet P; Castilla-Llorente C; Solary E; Durey MA; Rubio MT; Hermine O; Kohli E; Garrido C JCI Insight ä[]; 2 (6): ä PMID28352659show ga Better identification of severe acute graft-versus-host disease (GvHD) may improve the outcome of this life-threatening complication of allogeneic hematopoietic stem cell transplantation. GvHD induces tissue damage and the release of damage-associated molecular pattern (DAMP) molecules. Here, we analyzed GvHD patients (n = 39) to show that serum heat shock protein glycoprotein 96 (Gp96) could be such a DAMP molecule. We demonstrate that serum Gp96 increases in gastrointestinal GvHD patients and its level correlates with disease severity. An increase in Gp96 serum level was also observed in a mouse model of acute GvHD. This model was used to identify complement C3 as a main partner of Gp96 in the serum. Our biolayer interferometry, yeast two-hybrid and in silico modeling data allowed us to determine that Gp96 binds to a complement C3 fragment encompassing amino acids 749?954, a functional complement C3 hot spot important for binding of different regulators. Accordingly, in vitro experiments with purified proteins demonstrate that Gp96 downregulates several complement C3 functions. Finally, experimental induction of GvHD in complement C3?deficient mice confirms the link between Gp96 and complement C3 in the serum and with the severity of the disease. äSerum Gp96 is a chaperone of complement-C3 during graft-versus-host di(epmc).pdf DeepDyve Pubget Overpricing