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2017 ; 144
(6
): 958-962
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English Wikipedia
Pluripotent stem cell-derived organoids: using principles of developmental
biology to grow human tissues in a dish
#MMPMID28292841
McCauley HA
; Wells JM
Development
2017[Mar]; 144
(6
): 958-962
PMID28292841
show ga
Pluripotent stem cell (PSC)-derived organoids are miniature, three-dimensional
human tissues generated by the application of developmental biological principles
to PSCs in vitro The approach to generate organoids uses a combination of
directed differentiation, morphogenetic processes, and the intrinsically driven
self-assembly of cells that mimics organogenesis in the developing embryo. The
resulting organoids have remarkable cell type complexity, architecture and
function similar to their in vivo counterparts. In the past five years, human
PSC-derived organoids with components of all three germ layers have been
generated, resulting in the establishment of a new human model system. Here, and
in the accompanying poster, we provide an overview of how principles of
developmental biology have been essential for generating human organoids in
vitro, and how organoids are now being used as a primary research tool to
investigate human developmental biology.