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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Sci+(Weinh)
2017 ; 4
(3
): 1600308
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Photo-Cross-Linked Dual-Responsive Hollow Capsules Mimicking Cell Membrane for
Controllable Cargo Post-Encapsulation and Release
#MMPMID28331784
Liu X
; Appelhans D
; Wei Q
; Voit B
Adv Sci (Weinh)
2017[Mar]; 4
(3
): 1600308
PMID28331784
show ga
Multifunctional and responsive hollow capsules are ideal candidates to establish
highly sophisticated compartments mimicking cell membranes for controllable
bio-inspired functions. For this purpose pH and temperature dual-responsive and
photo-cross-linked hollow capsules, based on silica-templated layer-by-layer
approach by using poly(N-isopropyl acrylamide)-block-polymethacrylate) and
polyallylamine, have been prepared to use them for the subsequent and easily
available post-encapsulation process of protein-like macromolecules at room
temperature and pH 7.4 and their controllable release triggered by stimuli. The
uptake and release properties of the hollow capsules for cargos are highly
affected by changes in the external stimuli temperature (25, 37, or 45 °C) and
internal stimuli pH of the phosphate-containing buffer solution (5.5 or 7.4), by
the degree of photo-cross-linking, and the size of cargo. The photo-cross-linked
and dual stimuli-responsive hollow capsules with different membrane permeability
can be considered as attractive material for mimicking cell functions triggered
by controllable uptake and release of different up to 11 nm sized biomolecules.