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10.1038/ncomms14617 http://scihub22266oqcxt.onion/10.1038/ncomms14617 C5357865!5357865!28303888     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28303888|t=2017. DNA methylation signatures in peripheral blood strongly predict all-cause mortality |pdf=|usr=}}{{28303888}} gab.com Text DNA methylation signatures in peripheral blood strongly predict all-cause mortality JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28303888 #FOAvip DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation to identify mortality-related DNAm signatures in a general population-based cohort with up to 14 years follow-up. In the discovery panel in a case-cohort approach, 11,063 CpGs reach genome-wide significance (FDR<0.05). 58 CpGs, mapping to 38 well-known disease-related genes and 14 intergenic regions, are confirmed in a validation panel. A mortality risk score based on ten selected CpGs exhibits strong association with all-cause mortality, showing hazard ratios (95% CI) of 2.16 (1.10?4.24), 3.42 (1.81?6.46) and 7.36 (3.69?14.68), respectively, for participants with scores of 1, 2?5 and 5+ compared with a score of 0. These associations are confirmed in an independent cohort and are independent from the ?epigenetic clock'. In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes. The DNAm-based risk score might be informative for risk assessment and stratification. Twit Text FOAVip DNA methylation signatures in peripheral blood strongly predict all-cause mortality ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28303888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28303888 #FOAvip English Wikipedia <ref>{{Cite pmid|28303888}}</ref> DNA methylation signatures in peripheral blood strongly predict all-cause mortality #MMPMID28303888 Zhang Y; Wilson R; Heiss J; Breitling LP; Saum KU; Schöttker B; Holleczek B; Waldenberger M; Peters A; Brenner H Nat Commun 2017[]; 8 (ä): ä PMID28303888show ga DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation to identify mortality-related DNAm signatures in a general population-based cohort with up to 14 years follow-up. In the discovery panel in a case-cohort approach, 11,063 CpGs reach genome-wide significance (FDR<0.05). 58 CpGs, mapping to 38 well-known disease-related genes and 14 intergenic regions, are confirmed in a validation panel. A mortality risk score based on ten selected CpGs exhibits strong association with all-cause mortality, showing hazard ratios (95% CI) of 2.16 (1.10?4.24), 3.42 (1.81?6.46) and 7.36 (3.69?14.68), respectively, for participants with scores of 1, 2?5 and 5+ compared with a score of 0. These associations are confirmed in an independent cohort and are independent from the ?epigenetic clock'. In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes. The DNAm-based risk score might be informative for risk assessment and stratification. äDNA methylation signatures in peripheral blood strongly predict all-ca(epmc).pdf DeepDyve Pubget Overpricing