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10.3389/fphys.2017.00162 http://scihub22266oqcxt.onion/10.3389/fphys.2017.00162 C5357659!5357659 !28373845     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28373845 &cmd=llinks): Failed to open stream: HTTP request failed! 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Perfused Gills Reveal Fundamental Principles of pH Regulation and Ammonia Homeostasis in the Cephalopod Octopus vulgaris |pdf=|usr=}}{{28373845 }} gab.com Text Perfused Gills Reveal Fundamental Principles of pH Regulation and Ammonia Homeostasis in the Cephalopod Octopus vulgaris JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28373845 #FOAvip In contrast to terrestrial animals most aquatic species can be characterized by relatively higher blood [Formula: see text] concentrations despite its potential toxicity to the central nervous system. Although many aquatic species excrete [Formula: see text] via specialized epithelia little information is available regarding the mechanistic basis for NH(3)/[Formula: see text] homeostasis in molluscs. Using perfused gills of Octopus vulgaris we studied acid-base regulation and ammonia excretion pathways in this cephalopod species. The octopus gill is capable of regulating ammonia (NH(3)/[Formula: see text]) homeostasis by the accumulation of ammonia at low blood levels (<260 ?M) and secretion at blood ammonia concentrations exceeding in vivo levels of 300 ?M. [Formula: see text] transport is sensitive to the adenylyl cyclase inhibitor KH7 indicating that this process is mediated through cAMP-dependent pathways. The perfused octopus gill has substantial pH regulatory abilities during an acidosis, accompanied by an increased secretion of [Formula: see text]. Immunohistochemical and qPCR analyses revealed tissue specific expression and localization of Na(+)/K(+)-ATPase, V-type H(+)-ATPase, Na(+)/H(+)-exchanger 3, and Rhesus protein in the gill. Using the octopus gill as a molluscan model, our results highlight the coupling of acid-base regulation and nitrogen excretion, which may represent a conserved pH regulatory mechanism across many marine taxa. Twit Text FOAVip Perfused Gills Reveal Fundamental Principles of pH Regulation and Ammonia Homeostasis in the Cephalopod Octopus vulgaris ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28373845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28373845 #FOAvip English Wikipedia <ref>{{Cite pmid|28373845 }}</ref> Perfused Gills Reveal Fundamental Principles of pH Regulation and Ammonia Homeostasis in the Cephalopod Octopus vulgaris #MMPMID28373845 Hu MY ; Sung PH ; Guh YJ ; Lee JR ; Hwang PP ; Weihrauch D ; Tseng YC Front Physiol 2017[]; 8 (ä): 162 PMID28373845 show ga In contrast to terrestrial animals most aquatic species can be characterized by relatively higher blood [Formula: see text] concentrations despite its potential toxicity to the central nervous system. Although many aquatic species excrete [Formula: see text] via specialized epithelia little information is available regarding the mechanistic basis for NH(3)/[Formula: see text] homeostasis in molluscs. Using perfused gills of Octopus vulgaris we studied acid-base regulation and ammonia excretion pathways in this cephalopod species. The octopus gill is capable of regulating ammonia (NH(3)/[Formula: see text]) homeostasis by the accumulation of ammonia at low blood levels (<260 ?M) and secretion at blood ammonia concentrations exceeding in vivo levels of 300 ?M. [Formula: see text] transport is sensitive to the adenylyl cyclase inhibitor KH7 indicating that this process is mediated through cAMP-dependent pathways. The perfused octopus gill has substantial pH regulatory abilities during an acidosis, accompanied by an increased secretion of [Formula: see text]. Immunohistochemical and qPCR analyses revealed tissue specific expression and localization of Na(+)/K(+)-ATPase, V-type H(+)-ATPase, Na(+)/H(+)-exchanger 3, and Rhesus protein in the gill. Using the octopus gill as a molluscan model, our results highlight the coupling of acid-base regulation and nitrogen excretion, which may represent a conserved pH regulatory mechanism across many marine taxa. äPerfused Gills Reveal Fundamental Principles of pH Regulation and Ammo(epmc).pdf DeepDyve Pubget Overpricing