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10.1016/j.kint.2016.08.035 http://scihub22266oqcxt.onion/10.1016/j.kint.2016.08.035 C5357451!5357451!27914702     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2017 ; 91 (4): 790-6 Nephropedia Template TP {{tp|p=27914702|t=2017. RENAL XENOTRANSPLANTATION: EXPERIMENTAL PROGRESS AND CLINICAL PROSPECTS |pdf=|usr=}}{{27914702}} gab.com Text RENAL XENOTRANSPLANTATION: EXPERIMENTAL PROGRESS AND CLINICAL PROSPECTS JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27914702 #FOAvip There are >100,000 patients waiting for kidney transplants in the US, and a vast need worldwide. Xenotransplantation, in the form of the transplantation of kidneys from genetically-engineered pigs, offers the possibility of overcoming the chronic shortage of deceased and living human donors. These genetic manipulations can take the form of (i) knockout of pig genes that are responsible for the expression of antigens against which the primate (human or nonhuman primate) has natural ?preformed? antibodies that bind and initiate complement-mediated destruction, or (ii) the insertion of human transgenes that provide protection against the human complement, coagulation, or inflammatory responses. Between 1989 and 2015, pig kidney graft survival in nonhuman primates increased from 23 days to almost 10 months. There appear to be no clinically significant physiological incompatibilities in renal function between pig and primate. The organ-source pigs will be housed in a biosecure environment, and thus the risk of transferring an exogenous potentially pathogenic microorganism will be less than after allotransplantation. Although the risk associated with porcine endogenous retroviruses is considered small, techniques are now available whereby they could potentially be excluded from the pig. The FDA suggests that xenotransplantation should be restricted to ?patients with serious or life-threatening diseases for whom adequately safe and effective alternative therapies are not available.? These might include those with (i) a high degree of allosensitization to human leukocyte antigens (HLA) or (ii) rapid recurrence of primary disease in previous allografts. The potential psychosocial, regulatory, and legal aspects of clinical xenotransplantation are briefly discussed. Twit Text FOAVip RENAL XENOTRANSPLANTATION: EXPERIMENTAL PROGRESS AND CLINICAL PROSPECTS ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27914702 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27914702 #FOAvip English Wikipedia <ref>{{Cite pmid|27914702}}</ref> RENAL XENOTRANSPLANTATION: EXPERIMENTAL PROGRESS AND CLINICAL PROSPECTS #MMPMID27914702 Wijkstrom M; Iwase H; Paris W; Hara H; Ezzelarab M; Cooper DKC Kidney Int 2017[Apr]; 91 (4): 790-6 PMID27914702show ga There are >100,000 patients waiting for kidney transplants in the US, and a vast need worldwide. Xenotransplantation, in the form of the transplantation of kidneys from genetically-engineered pigs, offers the possibility of overcoming the chronic shortage of deceased and living human donors. These genetic manipulations can take the form of (i) knockout of pig genes that are responsible for the expression of antigens against which the primate (human or nonhuman primate) has natural ?preformed? antibodies that bind and initiate complement-mediated destruction, or (ii) the insertion of human transgenes that provide protection against the human complement, coagulation, or inflammatory responses. Between 1989 and 2015, pig kidney graft survival in nonhuman primates increased from 23 days to almost 10 months. There appear to be no clinically significant physiological incompatibilities in renal function between pig and primate. The organ-source pigs will be housed in a biosecure environment, and thus the risk of transferring an exogenous potentially pathogenic microorganism will be less than after allotransplantation. Although the risk associated with porcine endogenous retroviruses is considered small, techniques are now available whereby they could potentially be excluded from the pig. The FDA suggests that xenotransplantation should be restricted to ?patients with serious or life-threatening diseases for whom adequately safe and effective alternative therapies are not available.? These might include those with (i) a high degree of allosensitization to human leukocyte antigens (HLA) or (ii) rapid recurrence of primary disease in previous allografts. The potential psychosocial, regulatory, and legal aspects of clinical xenotransplantation are briefly discussed. äRENAL XENOTRANSPLANTATION: EXPERIMENTAL PROGRESS AND CLINICAL PROSPECT(epmc).pdf DeepDyve Pubget Overpricing