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10.1002/glia.23121 http://scihub22266oqcxt.onion/10.1002/glia.23121 C5357187!5357187!28168732     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Glia 2017 ; 65 (5): 699-711 Nephropedia Template TP {{tp|p=28168732|t=2017. Two modes of enteric gliotransmission differentially affect gut physiology |pdf=|usr=}}{{28168732}} gab.com Text Two modes of enteric gliotransmission differentially affect gut physiology JO: Glia http://www.kidney.de/pget.php?&tw=1&pmid=28168732 #FOAvip Enteric glia (EG) in the enteric nervous system (ENS) can modulate neuronally regulated gut functions. Using molecular genetics, we assessed the effects that molecular entities expressed in EG and otherwise mediating two distinct mechanisms of gliotransmitter release, connexin 43 (Cx43) hemichannel vs. Ca2+-dependent exocytosis, have on gut function. The expression of mutated Cx43G138R (which favors hemichannel, as opposed to gap-junctional activity) in EG increased gut motility in vivo, while a knock-down of Cx43 in EG resulted in the reduction of gut motility. However, inhibition of Ca2+-dependent exocytosis in EG did not affect gut motility in vivo; rather, it increased the fecal pellet fluid content. Hampering either Cx43 expression or Ca2+-dependent exocytosis in EG had an effect on colonic migrating motor complexes, mainly decreasing frequency and velocity of contractions ex vivo. Thus, EG can differentially modulate gut reflexes using the above two distinct mechanisms of gliotransmission. Twit Text FOAVip Two modes of enteric gliotransmission differentially affect gut physiology ????Glia http://www.kidney.de/pget.php?&tw=1&pmid=28168732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28168732 #FOAvip English Wikipedia <ref>{{Cite pmid|28168732}}</ref> Two modes of enteric gliotransmission differentially affect gut physiology #MMPMID28168732 Grubi?i? V; Parpura V Glia 2017[May]; 65 (5): 699-711 PMID28168732show ga Enteric glia (EG) in the enteric nervous system (ENS) can modulate neuronally regulated gut functions. Using molecular genetics, we assessed the effects that molecular entities expressed in EG and otherwise mediating two distinct mechanisms of gliotransmitter release, connexin 43 (Cx43) hemichannel vs. Ca2+-dependent exocytosis, have on gut function. The expression of mutated Cx43G138R (which favors hemichannel, as opposed to gap-junctional activity) in EG increased gut motility in vivo, while a knock-down of Cx43 in EG resulted in the reduction of gut motility. However, inhibition of Ca2+-dependent exocytosis in EG did not affect gut motility in vivo; rather, it increased the fecal pellet fluid content. Hampering either Cx43 expression or Ca2+-dependent exocytosis in EG had an effect on colonic migrating motor complexes, mainly decreasing frequency and velocity of contractions ex vivo. Thus, EG can differentially modulate gut reflexes using the above two distinct mechanisms of gliotransmission. äTwo modes of enteric gliotransmission differentially affect gut physio(epmc).pdf DeepDyve Pubget Overpricing