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10.1016/j.molcel.2017.01.032 http://scihub22266oqcxt.onion/10.1016/j.molcel.2017.01.032 C5357178!5357178!28262504     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2017 ; 65 (6): 1014-1028.e7 Nephropedia Template TP {{tp|p=28262504|t=2017. Mitochondrial Ca2+ Uniporter is a Mitochondrial Luminal Redox Sensor That Augments MCU Channel Activity |pdf=|usr=}}{{28262504}} gab.com Text Mitochondrial Ca2+ Uniporter is a Mitochondrial Luminal Redox Sensor That Augments MCU Channel Activity JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28262504 #FOAvip Ca2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial bioenergetics and cell function. The MCU complex is the major pathway by which these signals are integrated in mitochondria. Whether and how these coactive elements interact with MCU has not been established. As an approach towards understanding the regulation of MCU channel by oxidative milieu, we adapted inflammatory and hypoxia models. We identified the conserved cysteine 97 to be the only reactive thiol in human MCU that undergoes S-glutathionylation. Furthermore, biochemical, structural and superresolution imaging analysis revealed that MCU oxidation promotes MCU higher-order oligomer formation. Both oxidation and mutation of MCU Cys-97 exhibited persistent MCU channel activity with higher [Ca2+]m uptake rate, elevated mROS and enhanced [Ca2+]m overload-induced cell death. In contrast, these effects were largely independent of MCU interaction with its regulators. These findings reveal a distinct functional role for Cys-97 in ROS sensing and regulation of MCU activity. Twit Text FOAVip Mitochondrial Ca2+ Uniporter is a Mitochondrial Luminal Redox Sensor That Augments MCU Channel Activity ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28262504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28262504 #FOAvip English Wikipedia <ref>{{Cite pmid|28262504}}</ref> Mitochondrial Ca2+ Uniporter is a Mitochondrial Luminal Redox Sensor That Augments MCU Channel Activity #MMPMID28262504 Dong Z; Shanmughapriya S; Tomar D; Siddiqui N; Lynch S; Nemani N; Breves SL; Zhang X; Tripathi A; Palaniappan P; Riitano MF; Worth A; Seelam A; Carvalho E; Subbiah R; Jaña F; Soboloff J; Peng Y; Cheung JY; Joseph SK; Caplan J; Rajan S; Stathopulos PB; Madesh M Mol Cell 2017[Mar]; 65 (6): 1014-1028.e7 PMID28262504show ga Ca2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial bioenergetics and cell function. The MCU complex is the major pathway by which these signals are integrated in mitochondria. Whether and how these coactive elements interact with MCU has not been established. As an approach towards understanding the regulation of MCU channel by oxidative milieu, we adapted inflammatory and hypoxia models. We identified the conserved cysteine 97 to be the only reactive thiol in human MCU that undergoes S-glutathionylation. Furthermore, biochemical, structural and superresolution imaging analysis revealed that MCU oxidation promotes MCU higher-order oligomer formation. Both oxidation and mutation of MCU Cys-97 exhibited persistent MCU channel activity with higher [Ca2+]m uptake rate, elevated mROS and enhanced [Ca2+]m overload-induced cell death. In contrast, these effects were largely independent of MCU interaction with its regulators. These findings reveal a distinct functional role for Cys-97 in ROS sensing and regulation of MCU activity. äMitochondrial Ca2+ Uniporter is a Mitochondrial Luminal Redox Sensor T(epmc).pdf DeepDyve Pubget Overpricing