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10.1371/journal.pone.0173624 http://scihub22266oqcxt.onion/10.1371/journal.pone.0173624 C5357021!5357021 !28306745     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28306745 &cmd=llinks): Failed to open stream: HTTP request failed! 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Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation |pdf=|usr=}}{{28306745 }} gab.com Text Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28306745 #FOAvip Both nickel and cadmium compounds have been established as group I carcinogens for several decades. Despite over-whelming evidence of these compounds' carcinogenicity in humans, the specific underlying molecular mechanisms that govern metal induced cellular transformation remain unclear. In this study, we found that there were slightly different effects on decreased SLBP mRNA and protein as well as increased polyA H3.1 in our nickel exposed cells. This suggested that nickel and arsenic have similar effects on canonical histone mRNA transcription and translation. We also saw that the depletion of SLBP protein was reversed by inhibiting the proteosome. Finally, we showed that inhibiting the SLBP mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel's effects on SLBP may be mediated via epigenetic mechanisms. Taken together these results suggest a similar mechanism by which both arsenic and nickel may exert their carcinogenic effects. Twit Text FOAVip Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28306745 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28306745 #FOAvip English Wikipedia <ref>{{Cite pmid|28306745 }}</ref> Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation #MMPMID28306745 Jordan A ; Zhang X ; Li J ; Laulicht-Glick F ; Sun H ; Costa M PLoS One 2017[]; 12 (3 ): e0173624 PMID28306745 show ga Both nickel and cadmium compounds have been established as group I carcinogens for several decades. Despite over-whelming evidence of these compounds' carcinogenicity in humans, the specific underlying molecular mechanisms that govern metal induced cellular transformation remain unclear. In this study, we found that there were slightly different effects on decreased SLBP mRNA and protein as well as increased polyA H3.1 in our nickel exposed cells. This suggested that nickel and arsenic have similar effects on canonical histone mRNA transcription and translation. We also saw that the depletion of SLBP protein was reversed by inhibiting the proteosome. Finally, we showed that inhibiting the SLBP mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel's effects on SLBP may be mediated via epigenetic mechanisms. Taken together these results suggest a similar mechanism by which both arsenic and nickel may exert their carcinogenic effects. |Cadmium/*pharmacology [MESH] |Cell Line [MESH] |Epigenesis, Genetic [MESH] |Histones/genetics/metabolism [MESH] |Humans [MESH] |Nickel/*pharmacology [MESH] |Nuclear Proteins/*genetics [MESH] |RNA, Messenger/genetics [MESH]Nickel and cadmium-induced SLBP depletion: A potential pathway to meta(epmc).pdf DeepDyve Pubget Overpricing