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10.18632/oncotarget.12533

http://scihub22266oqcxt.onion/10.18632/oncotarget.12533
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C5356913!5356913!27732962
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suck abstract from ncbi


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pmid27732962      Oncotarget 2017 ; 8 (2): 3711-23
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  • Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation #MMPMID27732962
  • Liu Xg; Liu Y; Chen F
  • Oncotarget 2017[Jan]; 8 (2): 3711-23 PMID27732962show ga
  • Soluble fibrinogen-like protein 2 (sFGL2) is the soluble form of fibrinogen-like protein 2 belonging to the fibrinogen-related protein superfamily. It is now well characterized that sFGL2 is mainly secreted by regulatory T cell (Treg) populations, and exerts potently immunosuppressive activities. By repressing not only the differentiation and proliferation of T cells but also the maturation of dendritic cells (DCs), sFGL2 acts largely as an immunosuppressant. Moreover, sFGL2 also induces apoptosis of B cells, tubular epithelial cells (TECs), sinusoidal endothelial cells (SECs), and hepatocytes. This mini-review focuses primarily on the recent literature with respect to the signaling mechanism of sFGL2 in immunomodulation, and discusses the clinical implications of sFGL2 in transplantation, hepatitis, autoimmunity, and tumors.
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