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10.18632/oncotarget.13869 http://scihub22266oqcxt.onion/10.18632/oncotarget.13869 C5356901!5356901 !27974681     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27974681 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (2 ): 3528-3541 Nephropedia Template TP {{tp|p=27974681 |t=2017. Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption |pdf=|usr=}}{{27974681 }} gab.com Text Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974681 #FOAvip Tumor cells rely on high concentrations of amino acids to support their growth and proliferation. Although increased macropinocytic uptake and lysosomal degradation of the most abundant serum protein, albumin, in Ras-transformed cells can meet these demands, it is not understood how the majority of tumor cells that express wild type Ras achieve this. In the current study we reveal that the neonatal Fc receptor, FcRn, regulates tumor cell proliferation through the ability to recycle its ligand, albumin. By contrast with normal epithelial cells, we show that human FcRn is present at very low or undetectable levels in the majority of tumor cell lines analyzed. Remarkably, shRNA-mediated ablation of FcRn expression in an FcRn-positive tumor cell line results in a substantial growth increase of tumor xenografts, whereas enforced expression of this receptor by lentiviral transduction has the reverse effect. Moreover, intracellular albumin and glutamate levels are increased by the loss of FcRn-mediated recycling of albumin, combined with hypoalbuminemia in tumor-bearing mice. These studies identify a novel role for FcRn as a suppressor of tumor growth and have implications for the use of this receptor as a prognostic indicator and therapeutic target. Twit Text FOAVip Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27974681 #FOAvip English Wikipedia <ref>{{Cite pmid|27974681 }}</ref> Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption #MMPMID27974681 Swiercz R ; Mo M ; Khare P ; Schneider Z ; Ober RJ ; Ward ES Oncotarget 2017[Jan]; 8 (2 ): 3528-3541 PMID27974681 show ga Tumor cells rely on high concentrations of amino acids to support their growth and proliferation. Although increased macropinocytic uptake and lysosomal degradation of the most abundant serum protein, albumin, in Ras-transformed cells can meet these demands, it is not understood how the majority of tumor cells that express wild type Ras achieve this. In the current study we reveal that the neonatal Fc receptor, FcRn, regulates tumor cell proliferation through the ability to recycle its ligand, albumin. By contrast with normal epithelial cells, we show that human FcRn is present at very low or undetectable levels in the majority of tumor cell lines analyzed. Remarkably, shRNA-mediated ablation of FcRn expression in an FcRn-positive tumor cell line results in a substantial growth increase of tumor xenografts, whereas enforced expression of this receptor by lentiviral transduction has the reverse effect. Moreover, intracellular albumin and glutamate levels are increased by the loss of FcRn-mediated recycling of albumin, combined with hypoalbuminemia in tumor-bearing mice. These studies identify a novel role for FcRn as a suppressor of tumor growth and have implications for the use of this receptor as a prognostic indicator and therapeutic target. |*Gene Silencing [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Gene Expression [MESH] |Gene Knockdown Techniques [MESH] |Heterografts [MESH] |Histocompatibility Antigens Class I/*genetics/metabolism [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Male [MESH] |Mice [MESH] |Neoplasms/*genetics/*metabolism/pathology [MESH] |Receptors, Fc/*genetics/metabolism [MESH]Loss of expression of the recycling receptor, FcRn, promotes tumor cel(epmc).pdf DeepDyve Pubget Overpricing