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10.18632/oncotarget.13621

http://scihub22266oqcxt.onion/10.18632/oncotarget.13621
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C5356867!5356867!27902971
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suck abstract from ncbi


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pmid27902971      Oncotarget 2017 ; 8 (2): 3104-10
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  • Long non-coding RNA SPRY4-IT1 promotes gallbladder carcinoma progression #MMPMID27902971
  • Yang L; Cheng X; Ge N; Guo W; Feng F; Wan F
  • Oncotarget 2017[Jan]; 8 (2): 3104-10 PMID27902971show ga
  • Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. Long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including GBC. SPRY4-IT1 has been recently revealed as oncogenic regulator in many cancers. However, whether SPRY4-IT1 is involved in GBC progression remains largely unknown. To investigate the role of SPRY4-IT1 in GBC, we evaluated the expression SPRY4-IT1 in GBC tissues and cell lines, and investigated the effect of SPRY4-IT1 knockdown on cell proliferation, migration and invasion of GBC in vitro. Our result showed that SPRY4-IT1 was upregulated in GBC tissues. Further experiments revealed that SPRY4-IT1 knockdown significantly inhibited GBC cell proliferation. Furthermore, inhibitory effects of SPRY4-IT1 on cell migration and invasion were partly associated with EMT process. In conclusion, these data suggest that SPRY4-IT1 could be an oncogene for GBC, and may be served as a candidate target for new therapies in human GBC.
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