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2017 ; 8
(2
): 2356-2360
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gab.com Text
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English Wikipedia
Ketamine rapidly relieves acute suicidal ideation in cancer patients: a
randomized controlled clinical trial
#MMPMID27926528
Fan W
; Yang H
; Sun Y
; Zhang J
; Li G
; Zheng Y
; Liu Y
Oncotarget
2017[Jan]; 8
(2
): 2356-2360
PMID27926528
show ga
This study was designed to examine the rapid antidepressant effects of single
dose ketamine on suicidal ideation and overall depression level in patients with
newly-diagnosed cancer. Forty-two patients were enrolled into the controlled
trial and randomized into two groups: ketamine group and midazolam group.
Patients from the two groups received a sub-anesthetic dose of racemic ketamine
hydrochloride or midazolam. Suicidal ideation score, measured with the Beck Scale
and suicidal part of the Montgomery-Asberg Depression Rating Scale, significantly
decreased on day 1 and day 3 in ketamine-treated patients when compared to those
treated with midazolam. Consistently, overall depression levels measured using
the Montgomery-Asberg Depression Rating Scale indicated a significant relief of
overall depression on day 1 in ketamine-treated patients. Collectively, this
study provides novel information about the rapid antidepressant effect of
ketamine on acute depression and suicidal ideation in newly-diagnosed cancer
patients.