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10.18632/oncotarget.10502 http://scihub22266oqcxt.onion/10.18632/oncotarget.10502 C5356781!5356781!27409339     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (2): 2076-82 Nephropedia Template TP {{tp|p=27409339|t=2017. Nonlinear tumor evolution from dysplastic nodules to hepatocellular carcinoma |pdf=|usr=}}{{27409339}} gab.com Text Nonlinear tumor evolution from dysplastic nodules to hepatocellular carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27409339 #FOAvip Dysplastic nodules are premalignant neoplastic nodules found in explanted livers with cirrhosis. Genetic signatures of premalignant dysplastic nodules (DNs) with concurrent hepatocellular carcinoma (HCC) may provide an insight in the molecular evolution of hepatocellular carcinogenesis. We analyzed four patients with multifocal nodular lesions and cirrhotic background by whole-exome sequencing (WES). The genomic profiles of somatic single nucleotide variations (SNV) and copy number variations (CNV) in DNs were compared to those of HCCs. The number and variant allele frequency of somatic SNVs of DNs and HCCs in each patient was identical along the progression of pathological grade. The somatic SNVs in DNs showed little conservation in HCC. Additionally, CNVs showed no conservation. Phylogenetic analysis based on SNVs and copy number profiles indicated a nonlinear segregation pattern, implying independent development of DNs and HCC in each patient. Thus, somatic mutations in DNs may be developed separately from other malignant nodules in the same liver, suggesting a nonlinear model for hepatocarcinogenesis from DNs to HCC. Twit Text FOAVip Nonlinear tumor evolution from dysplastic nodules to hepatocellular carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27409339 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27409339 #FOAvip English Wikipedia <ref>{{Cite pmid|27409339}}</ref> Nonlinear tumor evolution from dysplastic nodules to hepatocellular carcinoma #MMPMID27409339 Joung JG; Ha SY; Seol Bae J; Nam JY; Gwak GY; Lee HO; Son DS; Park CK; Park WY Oncotarget 2017[Jan]; 8 (2): 2076-82 PMID27409339show ga Dysplastic nodules are premalignant neoplastic nodules found in explanted livers with cirrhosis. Genetic signatures of premalignant dysplastic nodules (DNs) with concurrent hepatocellular carcinoma (HCC) may provide an insight in the molecular evolution of hepatocellular carcinogenesis. We analyzed four patients with multifocal nodular lesions and cirrhotic background by whole-exome sequencing (WES). The genomic profiles of somatic single nucleotide variations (SNV) and copy number variations (CNV) in DNs were compared to those of HCCs. The number and variant allele frequency of somatic SNVs of DNs and HCCs in each patient was identical along the progression of pathological grade. The somatic SNVs in DNs showed little conservation in HCC. Additionally, CNVs showed no conservation. Phylogenetic analysis based on SNVs and copy number profiles indicated a nonlinear segregation pattern, implying independent development of DNs and HCC in each patient. Thus, somatic mutations in DNs may be developed separately from other malignant nodules in the same liver, suggesting a nonlinear model for hepatocarcinogenesis from DNs to HCC. äNonlinear tumor evolution from dysplastic nodules to hepatocellular ca(epmc).pdf DeepDyve Pubget Overpricing