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2017 ; 8
(2
): 2020-2024
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Medically uncontrolled conjunctival pyogenic granulomas: correlation between
clinical characteristics and histological findings
#MMPMID28008138
Wu D
; Qian T
; Nakao T
; Xu J
; Liu Z
; Sun X
; Chu Y
; Hong J
Oncotarget
2017[Jan]; 8
(2
): 2020-2024
PMID28008138
show ga
BACKGROUND: Conjunctival pyogenic granulomas are commonly seen after ocular
surgeries or at an ocular wound site. The aim of this study is to describe a
novel histological classification for medically uncontrolled conjunctival
pyogenic granulomas (MUCPG), and to explore whether the diversity in clinical
features correlates to different histological subtypes of MUCPG. METHODS: This is
an observational cross-section case series. We reviewed 46 consecutive patients
with conjunctival pyogenic granulomas who did not respond to topical
corticosteroids and underwent surgical excision from January 1, 2006 through
December 31, 2015. Clinical features and histological findings were presented and
analyzed. RESULTS: Ocular surgery, accidental injury, and chalazion were the main
predisposing causes of MUCPG. The lesions tended to occur unilaterally on the
bulbar conjunctiva. Forty patients (87%) presented an enrichment of inflammatory
cells and proliferated capillaries in their pathological sections (inflammatory
pattern). Six patients (13%) showed relatively few inflammatory cells and
capillaries within fibrous stroma (fibrous pattern). Patients with the
inflammatory pattern were older (p = 0.025) and tended to be located in bulbar
conjunctiva (p = 0.002). The predisposing causes were also different between two
histological subtypes (p = 0.007). CONCLUSIONS: We found the correlation between
clinical presentation and histological subtypes in patients with MUCPG,
indicating this disease may need a new classification scheme.