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10.18632/oncotarget.13000 http://scihub22266oqcxt.onion/10.18632/oncotarget.13000 C5356762!5356762 !27811354     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27811354 &cmd=llinks): Failed to open stream: HTTP request failed! 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Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma? An analysis from a large multicenter cohort study |pdf=|usr=}}{{27811354 }} gab.com Text Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma An analysis from a large multicenter cohort study JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27811354 #FOAvip PURPOSE: Whether the progression of advanced pancreatic ductal adenocarcinoma (PDAC) patients could be affected by HBV exposure remains to be determined. Therefore, we conducted this study to assess the effect of HBV infection on PDAC progression among a large cohort in China. METHODS: A multicenter cohort study was conducted to explore whether liver metastasis and overall survival in locally advanced and metastatic PDAC could be affected by HBV infection. In this study, we collected 1,526 advanced PDAC patients at three participating hospitals - Shanghai Cancer Center, Changhai Hospital and Ruijin Hospital from 2004 to 2013. The association between HBV status and advanced PDAC progression was then examined. RESULTS: In multivariable Logistic regression model, chronic hepatitis B(CHB) infection was inversely associated with synchronous liver metastasis compared to non HBV infection (OR 0.41, 95% CI 0.19-0.85) for stage IV patients. In a multivariable Cox model, CHB infection (HR=0.11, 95% CI 0.02-0.82) is considered as a protective factor of metachronous liver metastasis compared to Non HBV infection for stage III patients. For stage IV patients, CHB infection was inversely associated with overall survival compared to non HBV infection (HR 0.70, 95% CI 0.51-0.95). Inactive carrier(IC) and resolved HBV infection showed no significant association with survival compared to non HBV infection. CONCLUSION: This study indicated that CHB infection may serve as an independent factor which decrease synchronous or metachronous liver metastasis, and increase overall survival among advanced PDAC patients. Twit Text FOAVip Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma An analysis from a large multicenter cohort study ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27811354 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27811354 #FOAvip English Wikipedia <ref>{{Cite pmid|27811354 }}</ref> Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma? An analysis from a large multicenter cohort study #MMPMID27811354 Chen Q ; Ning Z ; Wang L ; Ying H ; Dong S ; Zhang C ; Shen X ; Guo Y ; Chen H ; Zhu X ; Shen Y ; Shi W ; Hua Y ; Wang K ; Lin J ; Xu L ; Chen L ; Feng L ; Zhang X ; Xie J ; Sun B ; Sun Y ; Gu W ; Kang M ; Tang Z ; Chen Z ; Chen Z ; Liu L ; Yu J ; Li Z ; Meng Z Oncotarget 2016[Dec]; 7 (51 ): 85603-85612 PMID27811354 show ga PURPOSE: Whether the progression of advanced pancreatic ductal adenocarcinoma (PDAC) patients could be affected by HBV exposure remains to be determined. Therefore, we conducted this study to assess the effect of HBV infection on PDAC progression among a large cohort in China. METHODS: A multicenter cohort study was conducted to explore whether liver metastasis and overall survival in locally advanced and metastatic PDAC could be affected by HBV infection. In this study, we collected 1,526 advanced PDAC patients at three participating hospitals - Shanghai Cancer Center, Changhai Hospital and Ruijin Hospital from 2004 to 2013. The association between HBV status and advanced PDAC progression was then examined. RESULTS: In multivariable Logistic regression model, chronic hepatitis B(CHB) infection was inversely associated with synchronous liver metastasis compared to non HBV infection (OR 0.41, 95% CI 0.19-0.85) for stage IV patients. In a multivariable Cox model, CHB infection (HR=0.11, 95% CI 0.02-0.82) is considered as a protective factor of metachronous liver metastasis compared to Non HBV infection for stage III patients. For stage IV patients, CHB infection was inversely associated with overall survival compared to non HBV infection (HR 0.70, 95% CI 0.51-0.95). Inactive carrier(IC) and resolved HBV infection showed no significant association with survival compared to non HBV infection. CONCLUSION: This study indicated that CHB infection may serve as an independent factor which decrease synchronous or metachronous liver metastasis, and increase overall survival among advanced PDAC patients. |Carcinoma, Pancreatic Ductal/*epidemiology/mortality/pathology [MESH] |Chi-Square Distribution [MESH] |China/epidemiology [MESH] |Disease Progression [MESH] |Female [MESH] |Hepatitis B, Chronic/diagnosis/*epidemiology/mortality [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Liver Neoplasms/*epidemiology/mortality/secondary [MESH] |Logistic Models [MESH] |Male [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Neoplasm Staging [MESH] |Odds Ratio [MESH] |Pancreatic Neoplasms/*epidemiology/mortality/pathology [MESH] |Proportional Hazards Models [MESH] |Prospective Studies [MESH] |Protective Factors [MESH] |Risk Assessment [MESH] |Risk Factors [MESH]Is chronic hepatitis B infection a protective factor for the progressi(epmc).pdf DeepDyve Pubget Overpricing