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10.18632/oncotarget.13236 http://scihub22266oqcxt.onion/10.18632/oncotarget.13236 C5356729!5356729 !27833079     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27833079 &cmd=llinks): Failed to open stream: HTTP request failed! 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Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis |pdf=|usr=}}{{27833079 }} gab.com Text Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27833079 #FOAvip The L1 cell adhesion molecule (L1CAM) extensively participates in nervous system development and the malignant progression of human tumours. The prognostic value of L1CAM for the survival of patients with solid tumours remains controversial. The present meta-analysis was thus performed to highlight the relationship between L1CAM expression and prognosis in cancer patients. Relevant publications were identified after searching several widely used databases, including PubMed, EMBASE and the ISI Web of Science. A fixed-effect or random-effect meta-analytical model was employed to correlate L1CAM expression with different outcome measures in both entire tumours and stratified subgroups. 37 studies in total with 8552 patients were eligible for the final analysis. Combined hazard ratios (HRs) and 95% confidence intervals (CIs) suggested that high L1CAM expression had an unfavourable impact on overall survival (HR=2.06, 95%CI 1.65-2.57, P<0.001), disease-specific survival (HR=2.45, 95%CI 1.48-4.05, P<0.001), disease-free survival (HR=2.42, 95%CI 1.4-4.19, P=0.002) and progression-free survival/recurrence-free survival (HR=2.07, 95%CI 1.41-3.05, P<0.001). Subgroup analysis revealed a similar correlation in most tumour types. Overall, L1CAM might be an effective poor prognostic factor for patients with various tumour types. Twit Text FOAVip Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27833079 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27833079 #FOAvip English Wikipedia <ref>{{Cite pmid|27833079 }}</ref> Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis #MMPMID27833079 Hua T ; Liu S ; Xin X ; Jin Z ; Liu Q ; Chi S ; Wang X ; Wang H Oncotarget 2016[Dec]; 7 (51 ): 85196-85207 PMID27833079 show ga The L1 cell adhesion molecule (L1CAM) extensively participates in nervous system development and the malignant progression of human tumours. The prognostic value of L1CAM for the survival of patients with solid tumours remains controversial. The present meta-analysis was thus performed to highlight the relationship between L1CAM expression and prognosis in cancer patients. Relevant publications were identified after searching several widely used databases, including PubMed, EMBASE and the ISI Web of Science. A fixed-effect or random-effect meta-analytical model was employed to correlate L1CAM expression with different outcome measures in both entire tumours and stratified subgroups. 37 studies in total with 8552 patients were eligible for the final analysis. Combined hazard ratios (HRs) and 95% confidence intervals (CIs) suggested that high L1CAM expression had an unfavourable impact on overall survival (HR=2.06, 95%CI 1.65-2.57, P<0.001), disease-specific survival (HR=2.45, 95%CI 1.48-4.05, P<0.001), disease-free survival (HR=2.42, 95%CI 1.4-4.19, P=0.002) and progression-free survival/recurrence-free survival (HR=2.07, 95%CI 1.41-3.05, P<0.001). Subgroup analysis revealed a similar correlation in most tumour types. Overall, L1CAM might be an effective poor prognostic factor for patients with various tumour types. |Biomarkers, Tumor/genetics/*metabolism [MESH] |Carcinogenesis [MESH] |Humans [MESH] |Neoplasms/*diagnosis/mortality [MESH] |Nervous System/*metabolism [MESH] |Neural Cell Adhesion Molecule L1/genetics/*metabolism [MESH] |Prognosis [MESH]Prognostic significance of L1 cell adhesion molecule in cancer patient(epmc).pdf DeepDyve Pubget Overpricing