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10.18632/oncotarget.13195 http://scihub22266oqcxt.onion/10.18632/oncotarget.13195 C5356720!5356720!27835880     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (51): 85063-78 Nephropedia Template TP {{tp|p=27835880|t=2016. Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma |pdf=|usr=}}{{27835880}} gab.com Text Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27835880 #FOAvip Oncogenic mutations in the PI3K/AKT pathway are present in nearly half of human tumors. Nonetheless, inhibitory compounds of the pathway often induce pathway rebound and tumor resistance. We find that lung squamous cell carcinoma (SQCC), which accounts for ~20% of lung cancer, exhibits increased expression of the PI3K subunit PIK3R2, which is at low expression levels in normal tissues. We tested a new approach to interfere with PI3K/AKT pathway activation in lung SQCC. We generated tumor xenografts of SQCC cell lines and examined the consequences of targeting PIK3R2 expression. In tumors with high PIK3R2 expression, and independently of PIK3CA, KRAS, or PTEN mutations, PIK3R2 depletion induced lung SQCC xenograft regression without triggering PI3K/AKT pathway rebound. These results validate the use PIK3R2 interfering tools for the treatment of lung squamous cell carcinoma. Twit Text FOAVip Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27835880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27835880 #FOAvip English Wikipedia <ref>{{Cite pmid|27835880}}</ref> Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma #MMPMID27835880 Vallejo-Díaz J; Olazabal-Morán M; Cariaga-Martínez AE; Pajares MJ; Flores JM; Pio R; Montuenga LM; Carrera AC Oncotarget 2016[Dec]; 7 (51): 85063-78 PMID27835880show ga Oncogenic mutations in the PI3K/AKT pathway are present in nearly half of human tumors. Nonetheless, inhibitory compounds of the pathway often induce pathway rebound and tumor resistance. We find that lung squamous cell carcinoma (SQCC), which accounts for ~20% of lung cancer, exhibits increased expression of the PI3K subunit PIK3R2, which is at low expression levels in normal tissues. We tested a new approach to interfere with PI3K/AKT pathway activation in lung SQCC. We generated tumor xenografts of SQCC cell lines and examined the consequences of targeting PIK3R2 expression. In tumors with high PIK3R2 expression, and independently of PIK3CA, KRAS, or PTEN mutations, PIK3R2 depletion induced lung SQCC xenograft regression without triggering PI3K/AKT pathway rebound. These results validate the use PIK3R2 interfering tools for the treatment of lung squamous cell carcinoma. äTargeted depletion of PIK3R2 induces regression of lung squamous cell (epmc).pdf DeepDyve Pubget Overpricing