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10.18632/oncotarget.13321 http://scihub22266oqcxt.onion/10.18632/oncotarget.13321 C5356702!5356702 !27863375     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27863375 &cmd=llinks): Failed to open stream: HTTP request failed! 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H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway |pdf=|usr=}}{{27863375 }} gab.com Text H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27863375 #FOAvip Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by assessing the effects of the PI3K/Akt pathway inhibitor LY294002 and the autophagy inhibitor chloroquine (CQ) on autophagy and apoptosis in NMR skin fibroblasts. Serum starvation, H2O2 treatment, and LY294002 treatment all increased the LC3-II/LC3-I ratio and numbers of double-membraned autophagosomes and autophagic vacuoles, and decreased levels of p70S6K, p-AktSer473, and p-AktThr308. By contrast, CQ treatment decreased p70S6K, AktSer473, and AktThr308 levels. The Bax/Bcl-2 ratio increased after 12 h of exposure to LY294002 or CQ. These data show that inhibiting the Akt pathway promotes autophagy and apoptosis in NMR skin fibroblasts. Furthermore, LY294002 or CQ treatment decreased caspase-3, p53, and HIF1-? levels, suggesting that serum starvation or H2O2 treatment increase autophagy and apoptosis in NMR skin fibroblasts by inhibiting the PI3K/Akt pathway. CQ-induced inhibition of late autophagy stages also prevented Akt activation and induced apoptosis. Finally, the HIF-1? and p53 pathways were involved in serum starvation- or H2O2-induced autophagy in NMR skin fibroblasts. Twit Text FOAVip H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27863375 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27863375 #FOAvip English Wikipedia <ref>{{Cite pmid|27863375 }}</ref> H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway #MMPMID27863375 Zhao S ; Li L ; Wang S ; Yu C ; Xiao B ; Lin L ; Cong W ; Cheng J ; Yang W ; Sun W ; Cui S Oncotarget 2016[Dec]; 7 (51 ): 84839-84850 PMID27863375 show ga Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by assessing the effects of the PI3K/Akt pathway inhibitor LY294002 and the autophagy inhibitor chloroquine (CQ) on autophagy and apoptosis in NMR skin fibroblasts. Serum starvation, H2O2 treatment, and LY294002 treatment all increased the LC3-II/LC3-I ratio and numbers of double-membraned autophagosomes and autophagic vacuoles, and decreased levels of p70S6K, p-AktSer473, and p-AktThr308. By contrast, CQ treatment decreased p70S6K, AktSer473, and AktThr308 levels. The Bax/Bcl-2 ratio increased after 12 h of exposure to LY294002 or CQ. These data show that inhibiting the Akt pathway promotes autophagy and apoptosis in NMR skin fibroblasts. Furthermore, LY294002 or CQ treatment decreased caspase-3, p53, and HIF1-? levels, suggesting that serum starvation or H2O2 treatment increase autophagy and apoptosis in NMR skin fibroblasts by inhibiting the PI3K/Akt pathway. CQ-induced inhibition of late autophagy stages also prevented Akt activation and induced apoptosis. Finally, the HIF-1? and p53 pathways were involved in serum starvation- or H2O2-induced autophagy in NMR skin fibroblasts. |Animals [MESH] |Apoptosis/drug effects [MESH] |Autophagy/drug effects [MESH] |Cells, Cultured [MESH] |Chloroquine/*pharmacology [MESH] |Chromones/pharmacology [MESH] |Fibroblasts/*metabolism/pathology [MESH] |Gene Expression Regulation [MESH] |Hydrogen Peroxide/metabolism [MESH] |Longevity [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Mole Rats/*physiology [MESH] |Morpholines/pharmacology [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Proto-Oncogene Proteins c-bcl-2/metabolism [MESH] |Ribosomal Protein S6 Kinases, 70-kDa/metabolism [MESH] |Signal Transduction/drug effects [MESH]H2O2 treatment or serum deprivation induces autophagy and apoptosis in(epmc).pdf DeepDyve Pubget Overpricing