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2016 ; 7
(51
): 84533-84543
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A network meta-analysis for toxicity of eight chemotherapy regimens in the
treatment of metastatic/advanced breast cancer
#MMPMID27811367
Zhang XH
; Hao S
; Gao B
; Tian WG
; Jiang Y
; Zhang S
; Guo LJ
; Luo DL
Oncotarget
2016[Dec]; 7
(51
): 84533-84543
PMID27811367
show ga
OBJECTIVE: To compare the incidence of toxicity of 8 different chemotherapy
regimens, including doxorubicin + paclitaxel, doxorubicin, capecitabine, CMF
(cyclophosphamide + methotrexate + 5-fluorouracil), FAC (fluorouracil +
doxorubicin + cyclophosphamide), doxorubicin + docetaxel, doxorubicin +
cyclophosphamide and paclitaxel in the treatment of metastatic/advanced breast
cancer. RESULTS: This network meta-analysis included 8 randomized controlled
trials (RCTs). The findings revealed that, with regard to capecitabine alone
regimen exhibited higher incidence of nausea/vomiting than doxorubicin +
paclitaxel regimen, doxorubicin alone regimen and paclitaxel alone regimen in the
treatment of patients with metastatic/advanced breast cancer (OR = 32.48, 95% CI
= 1.65~2340.57; OR = 22.75, 95% CI = 1.03~1923.52; OR = 59.63, 95% CI =
2.22~5664.88, respectively). Furthermore, doxorubicin + cyclophosphamide regimen
had lower incidence of febrile neutropenia than doxorubicin + docetaxel (OR =
0.17, 95% CI = 0.03~0.96). No significant difference in the incidence of
stomatitis was observed among eight chemotherapy regimens. MATERIALS AND METHODS:
We initially searched PubMed, Cochrane Library and Embase databases from the
founding of these databases to January 2016. Eligible studies investigating the 8
different chemotherapy regimens for treatment of metastatic/advanced breast
cancer were included for direct and indirect comparison. The odds ratio (OR) and
surface under the cumulative ranking curves (SUCRA) value of the incidence of
toxicity among eight chemotherapy regimens were analyzed. CONCLUSIONS:
Capecitabine alone regimen and doxorubicin + docetaxel regimen may have a more
frequent toxicity in the treatment of metastatic/advanced breast cancer.
|Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use
[MESH]