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10.18632/oncotarget.12609 http://scihub22266oqcxt.onion/10.18632/oncotarget.12609 C5356665!5356665 !27741519     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27741519 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (51 ): 84338-84358 Nephropedia Template TP {{tp|p=27741519 |t=2016. H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair |pdf=|usr=}}{{27741519 }} gab.com Text H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27741519 #FOAvip The improvement of solubility and/or dissolution rate of poorly soluble natural compounds is an ideal strategy to make them optimal candidates as new potential drugs. Accordingly, the allyl sulfur compounds and omega-3 fatty acids are natural hydrophobic compounds that exhibit two important combined properties: cardiovascular protection and antitumor activity. Here, we have synthesized and characterized a novel formulation of diallyl disulfide (DADS) and ?-linolenic acid (ALA) as protein-nanoemulsions (BAD-NEs), using ultrasounds. BAD-NEs are stable over time at room temperature and show antioxidant and radical scavenging property. These NEs are also optimal H2S slow-release donors and show a significant anti-proliferative effect on different human cancer cell lines: MCF-7 breast cancer and HuT 78 T-cell lymphoma cells. BAD-NEs are able to regulate the ERK1/2 pathway, inducing apoptosis and cell cycle arrest at the G0/G1 phase. We have also investigated their effect on cell proliferation of human adult stem/progenitor cells. Interestingly, BAD-NEs are able to improve the Lin- Sca1+ human cardiac progenitor cells (hCPC) proliferation. This stem cell growth stimulation is combined with the expression and activation of proteins involved in tissue-repair, such as P-AKT, ?-sma and connexin 43. Altogether, our results suggest that these antioxidant nanoemulsions might have potential application in selective cancer therapy and for promoting the muscle tissue repair. Twit Text FOAVip H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27741519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27741519 #FOAvip English Wikipedia <ref>{{Cite pmid|27741519 }}</ref> H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair #MMPMID27741519 Ciocci M ; Iorio E ; Carotenuto F ; Khashoggi HA ; Nanni F ; Melino S Oncotarget 2016[Dec]; 7 (51 ): 84338-84358 PMID27741519 show ga The improvement of solubility and/or dissolution rate of poorly soluble natural compounds is an ideal strategy to make them optimal candidates as new potential drugs. Accordingly, the allyl sulfur compounds and omega-3 fatty acids are natural hydrophobic compounds that exhibit two important combined properties: cardiovascular protection and antitumor activity. Here, we have synthesized and characterized a novel formulation of diallyl disulfide (DADS) and ?-linolenic acid (ALA) as protein-nanoemulsions (BAD-NEs), using ultrasounds. BAD-NEs are stable over time at room temperature and show antioxidant and radical scavenging property. These NEs are also optimal H2S slow-release donors and show a significant anti-proliferative effect on different human cancer cell lines: MCF-7 breast cancer and HuT 78 T-cell lymphoma cells. BAD-NEs are able to regulate the ERK1/2 pathway, inducing apoptosis and cell cycle arrest at the G0/G1 phase. We have also investigated their effect on cell proliferation of human adult stem/progenitor cells. Interestingly, BAD-NEs are able to improve the Lin- Sca1+ human cardiac progenitor cells (hCPC) proliferation. This stem cell growth stimulation is combined with the expression and activation of proteins involved in tissue-repair, such as P-AKT, ?-sma and connexin 43. Altogether, our results suggest that these antioxidant nanoemulsions might have potential application in selective cancer therapy and for promoting the muscle tissue repair. |Allyl Compounds/metabolism/*pharmacology [MESH] |Antineoplastic Agents/chemistry/metabolism/pharmacology [MESH] |Apoptosis/drug effects [MESH] |Cardiotonic Agents/chemistry/metabolism/pharmacology [MESH] |Cell Cycle/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/*drug effects [MESH] |Disulfides/metabolism/*pharmacology [MESH] |Emulsions/chemistry [MESH] |Female [MESH] |Humans [MESH] |Hydrogen Sulfide/*metabolism [MESH] |MCF-7 Cells [MESH] |Microscopy, Electron, Scanning [MESH] |Myocardium/cytology [MESH] |Nanostructures/chemistry/ultrastructure [MESH] |Neoplasms/metabolism/pathology [MESH]H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells (epmc).pdf DeepDyve Pubget Overpricing