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10.18632/oncotarget.6930 http://scihub22266oqcxt.onion/10.18632/oncotarget.6930 C5356639!5356639 !27824617     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27824617 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (51 ): 83976-83986 Nephropedia Template TP {{tp|p=27824617 |t=2016. Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation |pdf=|usr=}}{{27824617 }} gab.com Text Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27824617 #FOAvip Glioblastoma multiforme (GBM) is a malignant brain tumor with characteristics of strong aggressiveness which depend on vigorous microvascular supply. Vasculogenic mimicry (VM), a new microvascular circulation not involving endothelial cells, is reported as one part of the vascularization of GBM. Tumor-associated macrophages (TAMs), mostly present as immunosuppressive M2 phenotype in GBM, are well known as a promoter for tumor angiogenesis. However, whether TAMs can induce VM in GBM remains uncertain. In the present study, immunohistochemistry showed that higher numbers of macrophages infiltrating in the VM-positive area where tumor cells also highly express COX-2. By using the coculture model of U87 cell line and Interleukin-4-activated M2 macrophages, we found that the capability of VM formation was increased and COX-2 expression was up-regulated in U87 cells. Moreover, knockdown of COX-2 by siRNA Oligonucleotides or abrogating activity of COX-2 by specific inhibitors resulted in impairment of VM formation. Besides, in the process of VM formation, PGE2/EP1/PKC pathway was activated in U87 cells and inhibition of COX-2 led to down-regulation of PGE2 and PKC. In in vivo experiment, we found that COX-2 loss of function in the U87 xenograft model lead to less vascular mimicry. Collectively, our study demonstrates that M2 macrophages are capable of promoting generation of VM in GBM with COX-2 dependent, providing potential mechanisms of the interaction between inflammatory microenvironment and perivascular microenvironment. Twit Text FOAVip Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27824617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27824617 #FOAvip English Wikipedia <ref>{{Cite pmid|27824617 }}</ref> Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation #MMPMID27824617 Rong X ; Huang B ; Qiu S ; Li X ; He L ; Peng Y Oncotarget 2016[Dec]; 7 (51 ): 83976-83986 PMID27824617 show ga Glioblastoma multiforme (GBM) is a malignant brain tumor with characteristics of strong aggressiveness which depend on vigorous microvascular supply. Vasculogenic mimicry (VM), a new microvascular circulation not involving endothelial cells, is reported as one part of the vascularization of GBM. Tumor-associated macrophages (TAMs), mostly present as immunosuppressive M2 phenotype in GBM, are well known as a promoter for tumor angiogenesis. However, whether TAMs can induce VM in GBM remains uncertain. In the present study, immunohistochemistry showed that higher numbers of macrophages infiltrating in the VM-positive area where tumor cells also highly express COX-2. By using the coculture model of U87 cell line and Interleukin-4-activated M2 macrophages, we found that the capability of VM formation was increased and COX-2 expression was up-regulated in U87 cells. Moreover, knockdown of COX-2 by siRNA Oligonucleotides or abrogating activity of COX-2 by specific inhibitors resulted in impairment of VM formation. Besides, in the process of VM formation, PGE2/EP1/PKC pathway was activated in U87 cells and inhibition of COX-2 led to down-regulation of PGE2 and PKC. In in vivo experiment, we found that COX-2 loss of function in the U87 xenograft model lead to less vascular mimicry. Collectively, our study demonstrates that M2 macrophages are capable of promoting generation of VM in GBM with COX-2 dependent, providing potential mechanisms of the interaction between inflammatory microenvironment and perivascular microenvironment. |*Molecular Mimicry [MESH] |*Neovascularization, Pathologic [MESH] |*Tumor Microenvironment [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Brain Neoplasms/drug therapy/*enzymology/genetics/pathology [MESH] |Cell Line, Tumor [MESH] |Coculture Techniques [MESH] |Cyclooxygenase 2 Inhibitors/pharmacology [MESH] |Cyclooxygenase 2/genetics/*metabolism [MESH] |Dinoprostone/metabolism [MESH] |Disease-Free Survival [MESH] |Enzyme Activation [MESH] |Glioblastoma/drug therapy/*enzymology/genetics/pathology [MESH] |Human Umbilical Vein Endothelial Cells/enzymology [MESH] |Humans [MESH] |Macrophage Activation [MESH] |Macrophages/drug effects/*enzymology/pathology [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Phenotype [MESH] |Protein Kinase C/metabolism [MESH] |RNA Interference [MESH] |Receptors, Prostaglandin E, EP1 Subtype/metabolism [MESH] |Retrospective Studies [MESH] |Signal Transduction [MESH] |Time Factors [MESH] |Transfection [MESH]Tumor-associated macrophages induce vasculogenic mimicry of glioblasto(epmc).pdf DeepDyve Pubget Overpricing