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2016 ; 7
(42
): 69002-69013
Nephropedia Template TP
gab.com Text
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English Wikipedia
A network meta-analysis: the overall and progression-free survival of glioma
patients treated by different chemotherapeutic interventions combined with
radiation therapy (RT)
#MMPMID27458167
Qi L
; Ding L
; Wang S
; Zhong Y
; Zhao D
; Gao L
; Wang W
; Lv P
; Xu Y
; Wang S
Oncotarget
2016[Oct]; 7
(42
): 69002-69013
PMID27458167
show ga
Different chemotherapy drugs are generally introduced in clinical practices
combining with therapy for glioma treatment. However, these chemotherapy drugs
have rarely been compared with each other and the optimum drug still remains to
be proved. In this research, medical databases were consulted, PubMed, Embase and
Cochrane Library included. As primary outcomes, hazard ratio (HR) of overall
survival (OS) and progression-free survival (PFS) with their corresponding 95%
credential intervals (CrI) were reported. A network meta-analysis was conducted;
the surface under the cumulative ranking curve (SUCRA) was utilized for treatment
rank and a cluster analysis based on SUCRA values was performed. This research
includes 14 trials with 3,681 subjects and eight interventions. In terms of
network meta-analysis, placebo was proved to be inferior to the combination of
temozolomide (TMZ), nimustine (ACNU) and cisplatin (CDDP). Also, bevacizumab
(BEV) in conjunction with TMZ were significantly more effective than placebo with
an HR of 0.40. The estimated probabilities from SUCRA verified the above
outcomes, confirming that the combination of TMZ, ACNU and CDDP exhibited the
highest ranking probability of 0.889 with respect to OS, while BEV in combination
with TMZ - with a probability of 0.772 - ranked the first place with respect to
PFS. According to the results of this network meta-analysis, the combination of
(1) TMZ, ACNU and CDDP; (2) BEV in combination with TMZ and (3) cilengitide in
combination with TMZ, are considered as the preferable choices of chemotherapy
drugs for glioma treatment.
|*Chemoradiotherapy
[MESH]
|Antibodies, Monoclonal, Humanized
[MESH]
|Antineoplastic Agents/administration & dosage/*therapeutic use
[MESH]