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10.18632/oncotarget.11929 http://scihub22266oqcxt.onion/10.18632/oncotarget.11929 C5356584!5356584 !27626695     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27626695 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27626695 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (42 ): 68708-68720 Nephropedia Template TP {{tp|p=27626695 |t=2016. Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1? and Fra-1 / LSF- MMP2 / CD44 axes |pdf=|usr=}}{{27626695 }} gab.com Text Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1 and Fra-1 / LSF- MMP2 / CD44 axes JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27626695 #FOAvip Grifolin, a farnesyl phenolic compound isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, exhibits effective antitumor bioactivity in previous study of our group and other lab. In this study, we observed that grifolin inhibited tumor cells adhesion and migration. Moreover, grifolin reduced reactive oxygen species (ROS) production and caused cellular ATP depletion in high-metastatic tumor cells. PGC1? (Peroxisome proliferator-activated receptor ?, coactivator 1?) encodes a transcriptional co-activator involved in mitochondrial biogenesis and respiration and play a critical role in the maintenance of energy homeostasis. Interestingly, grifolin suppressed the mRNA as well as protein level of PGC1?. We further identified that MMP2 and CD44 expressions were PGC1? inducible. PGC1? can bind with metastatic-associated transcription factors: Fra-1 and LSF and the protein-protein interaction was attenuated by grifolin treatment. Overall, these findings suggest that grifolin decreased ROS generation and intracellular ATP to suppress tumor cell adhesion/migration via impeding the interplay between PGC1? and Fra-1 /LSF-MMP2/CD44 axes. Grifolin may develop as a promising lead compound for antitumor therapies by targeting energy metabolism regulator PGC1? signaling. Twit Text FOAVip Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1 and Fra-1 / LSF- MMP2 / CD44 axes ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27626695 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27626695 #FOAvip English Wikipedia <ref>{{Cite pmid|27626695 }}</ref> Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1? and Fra-1 / LSF- MMP2 / CD44 axes #MMPMID27626695 Luo X ; Li N ; Zhong J ; Tan Z ; Liu Y ; Dong X ; Cheng C ; Xu Z ; Li H ; Yang L ; Tang M ; Weng X ; Yi W ; Liu J ; Cao Y Oncotarget 2016[Oct]; 7 (42 ): 68708-68720 PMID27626695 show ga Grifolin, a farnesyl phenolic compound isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, exhibits effective antitumor bioactivity in previous study of our group and other lab. In this study, we observed that grifolin inhibited tumor cells adhesion and migration. Moreover, grifolin reduced reactive oxygen species (ROS) production and caused cellular ATP depletion in high-metastatic tumor cells. PGC1? (Peroxisome proliferator-activated receptor ?, coactivator 1?) encodes a transcriptional co-activator involved in mitochondrial biogenesis and respiration and play a critical role in the maintenance of energy homeostasis. Interestingly, grifolin suppressed the mRNA as well as protein level of PGC1?. We further identified that MMP2 and CD44 expressions were PGC1? inducible. PGC1? can bind with metastatic-associated transcription factors: Fra-1 and LSF and the protein-protein interaction was attenuated by grifolin treatment. Overall, these findings suggest that grifolin decreased ROS generation and intracellular ATP to suppress tumor cell adhesion/migration via impeding the interplay between PGC1? and Fra-1 /LSF-MMP2/CD44 axes. Grifolin may develop as a promising lead compound for antitumor therapies by targeting energy metabolism regulator PGC1? signaling. |Adenosine Triphosphate/metabolism [MESH] |Cell Adhesion/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects [MESH] |DNA-Binding Proteins/genetics/*metabolism [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Hyaluronan Receptors/genetics/*metabolism [MESH] |Matrix Metalloproteinase 2/genetics/*metabolism [MESH] |Neoplasms/genetics/metabolism/pathology [MESH] |Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics/*metabolism [MESH] |Proto-Oncogene Proteins c-fos/genetics/*metabolism [MESH] |Reactive Oxygen Species/metabolism [MESH] |Signal Transduction/drug effects/genetics [MESH] |Terpenes/pharmacology [MESH]Grifolin inhibits tumor cells adhesion and migration via suppressing i(epmc).pdf DeepDyve Pubget Overpricing