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10.18632/oncotarget.11919 http://scihub22266oqcxt.onion/10.18632/oncotarget.11919 C5356582!5356582 !27626692     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27626692 &cmd=llinks): Failed to open stream: HTTP request failed! 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Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1 |pdf=|usr=}}{{27626692 }} gab.com Text Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27626692 #FOAvip MiR-145 is a tumor-suppressive microRNA that participates in the malignant progression of colorectal cancer (CRC). Although miR-145 has been reported to inhibit proliferation and to induce apoptosis of CRC cells, the reports about its role in invasion and metastasis are controversial. The regulation of miR-145 its own expression also requires further elucidation. In this study, we firstly found that miR-145 is markedly downregulated in the metastatic tumors of CRC patients. Then through gain- and loss-of function studies, we demonstrated that miR-145 suppresses the invasion and metastasis of CRC cells. We also provided experimental evidences which include direct binding assays and verifications on tissue specimens to confirm that LIM and SH3 protein 1 (LASP1) is a direct target of miR-145. Furthermore, we identified the core promoter regions of miR-145 and observed the cooperation between histone methylation and transcription factors through binding to these core promoter regions to regulate the expression of miR-145 in CRC cells. Our study provides an insight into the regulatory network in CRC cells, thus offering new targets for treating CRC patients. Twit Text FOAVip Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27626692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27626692 #FOAvip English Wikipedia <ref>{{Cite pmid|27626692 }}</ref> Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1 #MMPMID27626692 Wang W ; Ji G ; Xiao X ; Chen X ; Qin WW ; Yang F ; Li YF ; Fan LN ; Xi WJ ; Huo Y ; Wen WH ; Yang AG ; Wang T Oncotarget 2016[Oct]; 7 (42 ): 68674-68687 PMID27626692 show ga MiR-145 is a tumor-suppressive microRNA that participates in the malignant progression of colorectal cancer (CRC). Although miR-145 has been reported to inhibit proliferation and to induce apoptosis of CRC cells, the reports about its role in invasion and metastasis are controversial. The regulation of miR-145 its own expression also requires further elucidation. In this study, we firstly found that miR-145 is markedly downregulated in the metastatic tumors of CRC patients. Then through gain- and loss-of function studies, we demonstrated that miR-145 suppresses the invasion and metastasis of CRC cells. We also provided experimental evidences which include direct binding assays and verifications on tissue specimens to confirm that LIM and SH3 protein 1 (LASP1) is a direct target of miR-145. Furthermore, we identified the core promoter regions of miR-145 and observed the cooperation between histone methylation and transcription factors through binding to these core promoter regions to regulate the expression of miR-145 in CRC cells. Our study provides an insight into the regulatory network in CRC cells, thus offering new targets for treating CRC patients. |*Gene Expression Regulation, Neoplastic [MESH] |Adaptor Proteins, Signal Transducing/*genetics/metabolism [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Colonic Neoplasms/*genetics/metabolism/pathology [MESH] |Colorectal Neoplasms/genetics/metabolism/pathology [MESH] |Cytoskeletal Proteins/*genetics/metabolism [MESH] |Epigenesis, Genetic [MESH] |Epithelial-Mesenchymal Transition/genetics [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |HCT116 Cells [MESH] |HEK293 Cells [MESH] |Histones/metabolism [MESH] |Humans [MESH] |LIM Domain Proteins/*genetics/metabolism [MESH] |Male [MESH] |Methylation [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |MicroRNAs/*genetics [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH]Epigenetically regulated miR-145 suppresses colon cancer invasion and (epmc).pdf DeepDyve Pubget Overpricing