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10.18632/oncotarget.6622 http://scihub22266oqcxt.onion/10.18632/oncotarget.6622 C5356533!5356533 !27626678     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27626678 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (42 ): 67986-68001 Nephropedia Template TP {{tp|p=27626678 |t=2016. Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation |pdf=|usr=}}{{27626678 }} gab.com Text Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27626678 #FOAvip Developing the Wnt pathway inhibitors has been considered as a therapeutic approach for cancers and other Wnt-related diseases. Previously we found that the G-rich sequence of WNT1 promoter is capable of forming G-quadruplex structure and stabilizing agents for Wnt1-mediated signaling pathway. Using a established cell-based drug screen system that enabled the evaluation of WNT1 expression activity in a G-quadruplex structure dependent manner, we evaluated a series of 6-substituted 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives that potentially inhibit the Wnt1-mediated signaling pathway. The most potent compound SJ26 showed repression of WNT1 activity in a G-quadruplex structure-dependent manner. Moreover, compound SJ26 inhibited the WNT1-mediated downstream signaling pathway and suppressed migration activity of cancer cells. Thus, we have identified a tetracyclic azafluorenone, SJ26, that is capable of binding to G-quadruplex DNA structure, repressing WNT1 expression, and inhibiting cell migration. Twit Text FOAVip Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27626678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27626678 #FOAvip English Wikipedia <ref>{{Cite pmid|27626678 }}</ref> Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation #MMPMID27626678 Chang LC ; Chen TC ; Chen SJ ; Chen CL ; Lee CC ; Wu SH ; Yen Y ; Huang HS ; Lin JJ Oncotarget 2016[Oct]; 7 (42 ): 67986-68001 PMID27626678 show ga Developing the Wnt pathway inhibitors has been considered as a therapeutic approach for cancers and other Wnt-related diseases. Previously we found that the G-rich sequence of WNT1 promoter is capable of forming G-quadruplex structure and stabilizing agents for Wnt1-mediated signaling pathway. Using a established cell-based drug screen system that enabled the evaluation of WNT1 expression activity in a G-quadruplex structure dependent manner, we evaluated a series of 6-substituted 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives that potentially inhibit the Wnt1-mediated signaling pathway. The most potent compound SJ26 showed repression of WNT1 activity in a G-quadruplex structure-dependent manner. Moreover, compound SJ26 inhibited the WNT1-mediated downstream signaling pathway and suppressed migration activity of cancer cells. Thus, we have identified a tetracyclic azafluorenone, SJ26, that is capable of binding to G-quadruplex DNA structure, repressing WNT1 expression, and inhibiting cell migration. |*G-Quadruplexes [MESH] |Antineoplastic Agents/chemistry/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects/genetics [MESH] |Cell Proliferation/drug effects/genetics [MESH] |DNA, Neoplasm/chemistry/genetics [MESH] |Fluorenes/chemistry/pharmacology [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Heterocyclic Compounds, 4 or More Rings/chemistry/pharmacology [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Molecular Structure [MESH] |Nucleic Acid Conformation/drug effects [MESH] |Promoter Regions, Genetic/genetics [MESH] |Wnt Signaling Pathway/*drug effects/genetics [MESH]Identification of a new class of WNT1 inhibitor: Cancer cells migratio(epmc).pdf DeepDyve Pubget Overpricing