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10.18632/oncotarget.11817 http://scihub22266oqcxt.onion/10.18632/oncotarget.11817 C5356532!5356532 !27602585     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27602585 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (42 ): 67966-67985 Nephropedia Template TP {{tp|p=27602585 |t=2016. Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1?/PKM2 axis in glioblastoma cells |pdf=|usr=}}{{27602585 }} gab.com Text Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1 /PKM2 axis in glioblastoma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602585 #FOAvip The human cytomegalovirus (HCMV) encoded chemokine receptor US28 promotes tumorigenesis through activation of various proliferative and angiogenic signaling pathways. Upon infection, US28 displays constitutive activity and signals in a G protein-dependent manner, hijacking the host's cellular machinery. In tumor cells, the hypoxia inducible factor-1?/pyruvate kinase M2 (HIF-1?/PKM2) axis plays an important role by supporting proliferation, angiogenesis and reprogramming of energy metabolism. In this study we show that US28 signaling results in activation of the HIF-1?/PKM2 feedforward loop in fibroblasts and glioblastoma cells. The constitutive activity of US28 increases HIF-1 protein stability through a G?q-, CaMKII- and Akt/mTOR-dependent mechanism. Furthermore, we found that VEGF and lactate secretion are increased and HIF-1 target genes, glucose transporter type 1 (GLUT1) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), involved in glucose metabolism, are upregulated in US28 expressing cells. In addition, PKM2 is phosphorylated and found to be in a tumor-associated dimeric state upon US28 expression. Also in HCMV-infected cells HIF-1 activity is enhanced, which in part is US28-dependent. Finally, increased proliferation of cells expressing US28 is abolished upon inhibition of the HIF-1?/PKM2 cascade. These data highlight the importance of HIF-1? and PKM2 in US28-induced proliferation, angiogenesis and metabolic reprogramming. Twit Text FOAVip Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1 /PKM2 axis in glioblastoma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602585 #FOAvip English Wikipedia <ref>{{Cite pmid|27602585 }}</ref> Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1?/PKM2 axis in glioblastoma cells #MMPMID27602585 de Wit RH ; Muji?-Deli? A ; van Senten JR ; Fraile-Ramos A ; Siderius M ; Smit MJ Oncotarget 2016[Oct]; 7 (42 ): 67966-67985 PMID27602585 show ga The human cytomegalovirus (HCMV) encoded chemokine receptor US28 promotes tumorigenesis through activation of various proliferative and angiogenic signaling pathways. Upon infection, US28 displays constitutive activity and signals in a G protein-dependent manner, hijacking the host's cellular machinery. In tumor cells, the hypoxia inducible factor-1?/pyruvate kinase M2 (HIF-1?/PKM2) axis plays an important role by supporting proliferation, angiogenesis and reprogramming of energy metabolism. In this study we show that US28 signaling results in activation of the HIF-1?/PKM2 feedforward loop in fibroblasts and glioblastoma cells. The constitutive activity of US28 increases HIF-1 protein stability through a G?q-, CaMKII- and Akt/mTOR-dependent mechanism. Furthermore, we found that VEGF and lactate secretion are increased and HIF-1 target genes, glucose transporter type 1 (GLUT1) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), involved in glucose metabolism, are upregulated in US28 expressing cells. In addition, PKM2 is phosphorylated and found to be in a tumor-associated dimeric state upon US28 expression. Also in HCMV-infected cells HIF-1 activity is enhanced, which in part is US28-dependent. Finally, increased proliferation of cells expressing US28 is abolished upon inhibition of the HIF-1?/PKM2 cascade. These data highlight the importance of HIF-1? and PKM2 in US28-induced proliferation, angiogenesis and metabolic reprogramming. |*Signal Transduction [MESH] |Animals [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Transformation, Neoplastic/genetics/metabolism [MESH] |Cells, Cultured [MESH] |Cytomegalovirus/physiology [MESH] |Fibroblasts/metabolism/virology [MESH] |Glioblastoma/genetics/*metabolism/virology [MESH] |HEK293 Cells [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism [MESH] |Male [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Mice [MESH] |NIH 3T3 Cells [MESH] |Receptors, Chemokine/genetics/*metabolism [MESH] |Thyroid Hormone-Binding Proteins [MESH] |Thyroid Hormones/genetics/*metabolism [MESH]Human cytomegalovirus encoded chemokine receptor US28 activates the HI(epmc).pdf DeepDyve Pubget Overpricing