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Elevated serum concentrations of HE4 as a novel biomarker of disease severity and
renal fibrosis in kidney disease
#MMPMID27589683
Wan J
; Wang Y
; Cai G
; Liang J
; Yue C
; Wang F
; Song J
; Wang J
; Liu M
; Luo J
; Li L
Oncotarget
2016[Oct]; 7
(42
): 67748-67759
PMID27589683
show ga
BACKGROUND: Human epididymis protein 4 (HE4), has recently been reported as a
mediator of renal fibrosis. However, serum HE4 levels appear in a large number of
patient samples with chronic kidney disease (CKD), and the relationship of these
levels to disease severity and renal fibrosis is unknown. METHODS: In 427
patients at different stages of CKD excluding gynecologic cancer and 173 healthy
subjects, serum HE4 concentrations were tested by chemiluminescent microparticle
immunoassay. Renal biopsy was performed on 259 of 427 subjects. Histological
findings were evaluated using standard immunohistochemistry. RESULTS: The levels
of serum HE4 were higher in CKD patients than in healthy subjects, and higher
levels were associated with more severe CKD stages. Patients with more severe
renal fibrosis tended to have higher HE4 levels, and correlation analysis showed
a significant correlation between HE4 and degree of renal fibrosis (r = 0.938, P
< 0.0001). HE4 can be a predictor of renal fibrosis in CKD patients; the area
under the receiver-operating characteristic curve (AUC-ROC) was 0.99, higher than
the AUC-ROC of serum creatinine (0.89). CONCLUSION: Elevated levels of serum HE4
are associated with decreased kidney function, and also with an advanced stage of
renal fibrosis, suggesting that HE4 may serve as a valuable clinical biomarker
for renal fibrosis of CKD.
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