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10.1182/blood-2016-09-731893 http://scihub22266oqcxt.onion/10.1182/blood-2016-09-731893 C5356454!5356454!28031180     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2017 ; 129 (11): 1420-7 Nephropedia Template TP {{tp|p=28031180|t=2017. Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts |pdf=|usr=}}{{28031180}} gab.com Text Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=28031180 #FOAvip Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular targets, and therapeutic approaches have been validated and translated into clinical practice. At the same time, the classification of mastocytosis and related diagnostic criteria have been refined and updated by the consensus group and the World Health Organization (WHO). As a result, more specific therapies tailored toward prognostic subgroups of patients have been developed. Emerging treatment concepts use drugs directed against KIT and other relevant targets in neoplastic mast cells and will hopefully receive recognition by health authorities in the near future. This article provides an overview of recent developments in the field, with emphasis on the updated WHO classification, refined criteria, additional prognostic parameters, and novel therapeutic approaches. Based on these emerging concepts, the prognosis, quality of life, and survival of patients with advanced mastocytosis are expected to improve in the coming years. Twit Text FOAVip Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=28031180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28031180 #FOAvip English Wikipedia <ref>{{Cite pmid|28031180}}</ref> Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts #MMPMID28031180 Valent P; Akin C; Metcalfe DD Blood 2017[Mar]; 129 (11): 1420-7 PMID28031180show ga Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular targets, and therapeutic approaches have been validated and translated into clinical practice. At the same time, the classification of mastocytosis and related diagnostic criteria have been refined and updated by the consensus group and the World Health Organization (WHO). As a result, more specific therapies tailored toward prognostic subgroups of patients have been developed. Emerging treatment concepts use drugs directed against KIT and other relevant targets in neoplastic mast cells and will hopefully receive recognition by health authorities in the near future. This article provides an overview of recent developments in the field, with emphasis on the updated WHO classification, refined criteria, additional prognostic parameters, and novel therapeutic approaches. Based on these emerging concepts, the prognosis, quality of life, and survival of patients with advanced mastocytosis are expected to improve in the coming years. äMastocytosis: 2016 updated WHO classification and novel emerging treat(epmc).pdf DeepDyve Pubget Overpricing