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2017 ; 14
(ä): 27
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Vitamin D: a possible modifying factor linking obesity to vascular calcification
in hemodialysis patients
#MMPMID28331532
Kim JK
; Park MJ
; Song YR
; Kim HJ
; Kim SG
Nutr Metab (Lond)
2017[]; 14
(ä): 27
PMID28331532
show ga
BACKGROUND: Obesity is a risk factor for increased cardiovascular disease.
Whether vitamin D deficiency modifies this association is unclear. Here, we
examined the association of obesity and vitamin D deficiency with vascular
calcification score (VCS) in incident end-stage renal disease (ESRD) patients.
METHODS: A cross-sectional study was conducted with 213 ESRD patients. Vitamin D
deficiency was defined as serum 25-hydroxyvitamin D (25(OH)D) levels below
10 ng/mL, and obesity was defined as a percentage of body fat (PBF) higher than
the sex-specific median value in the cohort (>26.8% for men, >36.2% for women).
VCS was measured by plain radiographic film of the lateral abdomen in the
standing position. RESULTS: Most ESRD patients (76.6%) had 25(OH)D deficiency at
the start of dialysis. The prevalence of 25(OH)D deficiency was much higher in
obese patients than non-obese patients, and it had significant inverse
association with PBF (r?=?-0.315, p?0.001). Abdominal aortic calcification was
identified in 104 (48.9%) patients. VCS was significantly higher in obese
population; 2.6 (0-23) for all patients, 4.2 (0-23) for obese and 1.0 (0-12) for
non-obese patients (p?0.001). Interestingly, vitamin D deficiency was
associated with greater risk of a high VCS, especially in obese population [odds
ratio (OR) 3.02, 95% confidence interval (CI) 1.09-9.38)], but not with non-obese
patients (OR 1.82, 95% CI 0.56-5.60). CONCLUSION: The magnitude and direction of
the association between obesity and the risk of vascular calcification may depend
on an individual's 25(OH)D level, a possible representative marker of
cardiometabolic disturbance in ESRD patients.