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http://scihub22266oqcxt.onion/ C5355840!5355840 !28331417     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28331417 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Yonago+Acta+Med 2017 ; 60 (1 ): 16-23 Nephropedia Template TP {{tp|p=28331417 |t=2017. ?-Tocotrienol Inhibits TGF-?1-Induced Contractile Phenotype Expression of Human Airway Smooth Muscle Cells |pdf=|usr=}}{{28331417 }} gab.com Text -Tocotrienol Inhibits TGF- 1-Induced Contractile Phenotype Expression of Human Airway Smooth Muscle Cells JO: Yonago Acta Med http://www.kidney.de/pget.php?&tw=1&pmid=28331417 #FOAvip BACKGROUND: Tocotrienols, members of the vitamin E family, exist in four different isoforms (?, ?, ? and ? tocotrienol) that have can be protective against brain damage, as well as having anticancer effects in vivo and in vitro. We have shown that ?-tocotrienol inhibits human airway smooth muscle cell proliferation and migration induced by platelet-derived growth factor (PDGF)-BB by suppressing RhoA activation. In this study, we tested whether ?-tocotrienol modulates transforming growth factor (TGF) -?-induced induction of human airway smooth muscle (ASM) into a contractile phenotype and concomitant synthesis of extracellular matrix proteins. METHODS: ASM cells were stimulated with TGF-?1 (2 ng/mL) for 48 hours and the effect of ?-tocotrienol (50 ?M) on ?-smooth muscle actin, fibronectin and collagen I expression was assessed using Western blotting. The signaling pathways involved in TGF-?1 stimulation were also investigated. RESULTS: TGF-?1 increased ?-smooth muscle actin, fibronectin and collagen ? abundance by 3- to 5-fold. This response was inhibited significantly by ?-tocotrienol. Furthermore, ?-tocotrienol suppressed RhoA activation, but did not affect Smad2 or Smad3 phosphorylation. CONCLUSION: These results indicate that ?-tocotrienol has potential for benefit in modulating on airway remodeling in asthma, likely via a mechanism involving the suppression of TGF-? activation of RhoA. Twit Text FOAVip -Tocotrienol Inhibits TGF- 1-Induced Contractile Phenotype Expression of Human Airway Smooth Muscle Cells ????Yonago Acta Med http://www.kidney.de/pget.php?&tw=1&pmid=28331417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28331417 #FOAvip English Wikipedia <ref>{{Cite pmid|28331417 }}</ref> ?-Tocotrienol Inhibits TGF-?1-Induced Contractile Phenotype Expression of Human Airway Smooth Muscle Cells #MMPMID28331417 Fukushima T ; Yamasaki A ; Harada T ; Chikumi H ; Watanabe M ; Okazaki R ; Takata M ; Hasegawa Y ; Kurai J ; Yanai M ; Yamamoto A ; Sueda Y ; Halayko AJ ; Shimizu E Yonago Acta Med 2017[Mar]; 60 (1 ): 16-23 PMID28331417 show ga BACKGROUND: Tocotrienols, members of the vitamin E family, exist in four different isoforms (?, ?, ? and ? tocotrienol) that have can be protective against brain damage, as well as having anticancer effects in vivo and in vitro. We have shown that ?-tocotrienol inhibits human airway smooth muscle cell proliferation and migration induced by platelet-derived growth factor (PDGF)-BB by suppressing RhoA activation. In this study, we tested whether ?-tocotrienol modulates transforming growth factor (TGF) -?-induced induction of human airway smooth muscle (ASM) into a contractile phenotype and concomitant synthesis of extracellular matrix proteins. METHODS: ASM cells were stimulated with TGF-?1 (2 ng/mL) for 48 hours and the effect of ?-tocotrienol (50 ?M) on ?-smooth muscle actin, fibronectin and collagen I expression was assessed using Western blotting. The signaling pathways involved in TGF-?1 stimulation were also investigated. RESULTS: TGF-?1 increased ?-smooth muscle actin, fibronectin and collagen ? abundance by 3- to 5-fold. This response was inhibited significantly by ?-tocotrienol. Furthermore, ?-tocotrienol suppressed RhoA activation, but did not affect Smad2 or Smad3 phosphorylation. CONCLUSION: These results indicate that ?-tocotrienol has potential for benefit in modulating on airway remodeling in asthma, likely via a mechanism involving the suppression of TGF-? activation of RhoA. ??-Tocotrienol Inhibits TGF-?1-Induced Contractile Phenotype Expression(epmc).pdf DeepDyve Pubget Overpricing