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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Microbiol+Rev
2017 ; 30
(2
): 557-596
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Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance
Mechanisms Encoded by Plasmids or Chromosomes
#MMPMID28275006
Poirel L
; Jayol A
; Nordmann P
Clin Microbiol Rev
2017[Apr]; 30
(2
): 557-596
PMID28275006
show ga
Polymyxins are well-established antibiotics that have recently regained
significant interest as a consequence of the increasing incidence of infections
due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are
being seriously reconsidered as last-resort antibiotics in many areas where
multidrug resistance is observed in clinical medicine. In parallel, the heavy use
of polymyxins in veterinary medicine is currently being reconsidered due to
increased reports of polymyxin-resistant bacteria. Susceptibility testing is
challenging with polymyxins, and currently available techniques are presented
here. Genotypic and phenotypic methods that provide relevant information for
diagnostic laboratories are presented. This review also presents recent works in
relation to recently identified mechanisms of polymyxin resistance, including
chromosomally encoded resistance traits as well as the recently identified
plasmid-encoded polymyxin resistance determinant MCR-1. Epidemiological features
summarizing the current knowledge in that field are presented.
|Anti-Bacterial Agents/pharmacology/therapeutic use
[MESH]