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2017 ; 25
(4
): 231-242
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gab.com Text
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Pathophysiology and treatment of atherosclerosis : Current view and future
perspective on lipoprotein modification treatment
#MMPMID28194698
Bergheanu SC
; Bodde MC
; Jukema JW
Neth Heart J
2017[Apr]; 25
(4
): 231-242
PMID28194698
show ga
Recent years have brought a significant amount of new results in the field of
atherosclerosis. A better understanding of the role of different lipoprotein
particles in the formation of atherosclerotic plaques is now possible. Recent
cardiovascular clinical trials have also shed more light upon the efficacy and
safety of novel compounds targeting the main pathways of atherosclerosis and its
cardiovascular complications.In this review, we first provide a background
consisting of the current understanding of the pathophysiology and treatment of
atherosclerotic disease, followed by our future perspectives on several novel
classes of drugs that target atherosclerosis. The focus of this update is on the
pathophysiology and medical interventions of low-density lipoprotein cholesterol
(LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and
lipoprotein(a) (Lp(a)).