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10.18632/oncotarget.13573

http://scihub22266oqcxt.onion/10.18632/oncotarget.13573
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C5355361!5355361!27888635
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suck abstract from ncbi

pmid27888635      Oncotarget 2017 ; 8 (7): 12517-32
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  • LncRNAs: the bridge linking RNA and colorectal cancer #MMPMID27888635
  • Yang Y; Zhao L; Lei L; Lau WB; Lau B; Yang Q; Le X; Yang H; Wang C; Luo Z; Xuan Y; Chen Y; Deng X; Xu L; Feng M; Yi T; Zhao X; Zhou S
  • Oncotarget 2017[Feb]; 8 (7): 12517-32 PMID27888635show ga
  • Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, and RNA. Recent studies have demonstrated that dysregulation of lncRNAs is influential in proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability in colorectal cancer (CRC), with consequent clinical implications. In this review, we explicate the roles of different lncRNAs in CRC, and the potential implications for their clinical application.
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