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2017 ; 8
(7
): 12472-12483
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The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the
epithelial-mesenchymal plasticity
#MMPMID27992370
Cao MX
; Jiang YP
; Tang YL
; Liang XH
Oncotarget
2017[Feb]; 8
(7
): 12472-12483
PMID27992370
show ga
Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene
regulation and encompass the well-known microRNAs (miRNAs), as well as the most
recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates
that lncRNAs can interact with miRNAs and these interactions play crucial roles
in cancer metastasis, through regulating critical events especially the
epithelial-mesenchymal transition (EMT). This review summarizes the types of
lncRNA-miRNA crosstalk identified to-date and discusses their influence on the
epithelial-mesenchymal plasticity and clinical metastatic implication.