Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28103577
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Association of RAB5 overexpression in pancreatic cancer with cancer progression
and poor prognosis via E-cadherin suppression
#MMPMID28103577
Igarashi T
; Araki K
; Yokobori T
; Altan B
; Yamanaka T
; Ishii N
; Tsukagoshi M
; Watanabe A
; Kubo N
; Handa T
; Hosouchi Y
; Nishiyama M
; Oyama T
; Shirabe K
; Kuwano H
Oncotarget
2017[Feb]; 8
(7
): 12290-12300
PMID28103577
show ga
Pancreatic cancer is a common type of cancer with poor prognosis worldwide.
Postoperative survival depends on the existence of metastasis. Elucidation of the
mechanism underlying cancer progression is important to improve prognosis. The
RAS-associated protein RAB5 activates intracellular membrane trafficking, and
RAB5 expression is correlated to progression and epithelial mesenchymal
transition in various cancers.The expression of RAB5 and E-cadherin in 111
pancreatic cancer samples was investigated by immunohistochemical staining, and
the relationship among RAB5 expression, clinicopathological factors, and
E-cadherin expression was assessed. Furthermore, RAB5 suppression analysis by
siRNA was performed to determine the roles of RAB5 in morphological change,
proliferation potency, cell migration ability, and invasiveness of the pancreatic
cancer cell line.High RAB5 expression correlated with the presence of lymphatic
invasion and venous invasion and low E-cadherin expression. Patients with high
RAB5 expression had a poorer prognosis than those with low RAB5 expression. RAB5
suppression in pancreatic cancer cells enhanced E-cadherin expression; changed
cell morphology from spindle to round; and inhibited proliferation, invasion, and
cell migration.RAB5 contributes to poor prognosis and progression in pancreatic
cancer patients. It may be a promising candidate for individualized therapy in
refractory pancreatic cancer.
free
free
free
