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10.18632/oncotarget.14415 http://scihub22266oqcxt.onion/10.18632/oncotarget.14415 C5355308!5355308!28060746     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (7): 11841-54 Nephropedia Template TP {{tp|p=28060746|t=2017. Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth |pdf=|usr=}}{{28060746}} gab.com Text Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28060746 #FOAvip Mitochondria can be involved in regulating cellular stress response to hypoxia and tumor growth, but little is known about that mechanistic relationship. Here, we show that mitochondrial deficiency severely retards tumor xenograft growth with impairing hypoxic induction of HIF-1 transcriptional activity. Using mtDNA-deficient ?0 cells, we found that HIF-1 pathway activation was comparable in slow-growing ?0 xenografts and rapid-growing parental xenografts. Interestingly, we found that ex vivo ?0 cells derived from ?0 xenografts exhibited slightly increased HIF-1? expression and modest HIF-1 pathway activation regardless of oxygen concentration. Surprisingly, ?0 cells, as well as parental cells treated with oxidative phosphorylation inhibitors, were unable to boost HIF-1 transcriptional activity during hypoxia, although HIF-1? protein levels were ordinarily increased in these cells under hypoxic conditions. These findings indicate that mitochondrial deficiency causes loss of hypoxia-induced HIF-1 transcriptional activity and thereby might lead to a constitutive HIF-1 pathway activation as a cellular adaptation mechanism in tumor microenvironment. Twit Text FOAVip Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28060746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28060746 #FOAvip English Wikipedia <ref>{{Cite pmid|28060746}}</ref> Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth #MMPMID28060746 Koido M; Haga N; Furuno A; Tsukahara S; Sakurai J; Tani Y; Sato S; Tomida A Oncotarget 2017[Feb]; 8 (7): 11841-54 PMID28060746show ga Mitochondria can be involved in regulating cellular stress response to hypoxia and tumor growth, but little is known about that mechanistic relationship. Here, we show that mitochondrial deficiency severely retards tumor xenograft growth with impairing hypoxic induction of HIF-1 transcriptional activity. Using mtDNA-deficient ?0 cells, we found that HIF-1 pathway activation was comparable in slow-growing ?0 xenografts and rapid-growing parental xenografts. Interestingly, we found that ex vivo ?0 cells derived from ?0 xenografts exhibited slightly increased HIF-1? expression and modest HIF-1 pathway activation regardless of oxygen concentration. Surprisingly, ?0 cells, as well as parental cells treated with oxidative phosphorylation inhibitors, were unable to boost HIF-1 transcriptional activity during hypoxia, although HIF-1? protein levels were ordinarily increased in these cells under hypoxic conditions. These findings indicate that mitochondrial deficiency causes loss of hypoxia-induced HIF-1 transcriptional activity and thereby might lead to a constitutive HIF-1 pathway activation as a cellular adaptation mechanism in tumor microenvironment. äMitochondrial deficiency impairs hypoxic induction of HIF-1 transcript(epmc).pdf DeepDyve Pubget Overpricing