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10.18632/oncotarget.14274 http://scihub22266oqcxt.onion/10.18632/oncotarget.14274 C5355294!5355294!28035065     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (7): 11659-75 Nephropedia Template TP {{tp|p=28035065|t=2017. ZGDHu-1 promotes apoptosis of mantle cell lymphoma cells |pdf=|usr=}}{{28035065}} gab.com Text ZGDHu-1 promotes apoptosis of mantle cell lymphoma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28035065 #FOAvip Mantle cell lymphoma (MCL) is a well-defined aggressive Non-Hodgkin-lymphoma with short survival rates and remains incurable to date. Previously, we demonstrated the antitumor activity of ZGDHu-1(N, N?-di-(m-methylphenyi)-3, 6-dimethyl-1, 4-dihydro-1, 2, 4, 5-tetrazine-1, 4-dicarboamide) in chronic lymphocytic leukemia. In this study, ZGDHu-1 shows potent anti-lymphoma activity in MCL cells. ZGDHu-1 significantly induces cell cycle G2/M phase arrest and apoptosis in MCL cells. ZGDHu-1 reduces the protein levels of Mcl-1, Bcl-XL and cyclin D1. Importantly, ZGDHu-1 inhibits TNF?-induced IkBa phosphorylation, p65 nuclear translocation and NF-kB downstream target gene expression in MCL cells. MCL samples expressing high levels of Bcl-2 and high Bcl-2/Bax ratios tend to be less effective to ZGDHu-1. Together, these results suggest that ZGDHu-1 could inhibit the NF-kB signaling pathway partly, which may lead to the suppression of cell proliferation and the induction of apoptosis in MCL cells. Thus, our studies provide evidence of the potential of ZGDHu-1 in treating mantle cell lymphoma. Twit Text FOAVip ZGDHu-1 promotes apoptosis of mantle cell lymphoma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28035065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28035065 #FOAvip English Wikipedia <ref>{{Cite pmid|28035065}}</ref> ZGDHu-1 promotes apoptosis of mantle cell lymphoma cells #MMPMID28035065 Qiu L; Liu J; Wang Z; Chen S; Hu W; Huang Q; Zhou Y Oncotarget 2017[Feb]; 8 (7): 11659-75 PMID28035065show ga Mantle cell lymphoma (MCL) is a well-defined aggressive Non-Hodgkin-lymphoma with short survival rates and remains incurable to date. Previously, we demonstrated the antitumor activity of ZGDHu-1(N, N?-di-(m-methylphenyi)-3, 6-dimethyl-1, 4-dihydro-1, 2, 4, 5-tetrazine-1, 4-dicarboamide) in chronic lymphocytic leukemia. In this study, ZGDHu-1 shows potent anti-lymphoma activity in MCL cells. ZGDHu-1 significantly induces cell cycle G2/M phase arrest and apoptosis in MCL cells. ZGDHu-1 reduces the protein levels of Mcl-1, Bcl-XL and cyclin D1. Importantly, ZGDHu-1 inhibits TNF?-induced IkBa phosphorylation, p65 nuclear translocation and NF-kB downstream target gene expression in MCL cells. MCL samples expressing high levels of Bcl-2 and high Bcl-2/Bax ratios tend to be less effective to ZGDHu-1. Together, these results suggest that ZGDHu-1 could inhibit the NF-kB signaling pathway partly, which may lead to the suppression of cell proliferation and the induction of apoptosis in MCL cells. Thus, our studies provide evidence of the potential of ZGDHu-1 in treating mantle cell lymphoma. äZGDHu-1 promotes apoptosis of mantle cell lymphoma cells (epmc).pdf DeepDyve Pubget Overpricing