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10.18632/oncotarget.14529 http://scihub22266oqcxt.onion/10.18632/oncotarget.14529 C5355270!5355270 !28076327     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28076327 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (7 ): 11356-11371 Nephropedia Template TP {{tp|p=28076327 |t=2017. MiR-410 induces stemness by inhibiting Gsk3? but upregulating ?-catenin in non-small cells lung cancer |pdf=|usr=}}{{28076327 }} gab.com Text MiR-410 induces stemness by inhibiting Gsk3 but upregulating -catenin in non-small cells lung cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28076327 #FOAvip Our previous research indicated miR-410 played a critical role in promoting the tumorigenesis and development of NSCLC (non-small cells lung cancer). MiR-410 has been recently reported to be crucial for development and differentiation of embryonic stem cells. But it remains elusive whether miR-410 stimulates the stemness of cancer until now. Herein, we identify miR-410 induces the stemness and is associated with the progression of NSCLC. We demonstrate miR-410 increases the levels of stem cells marker Sox2, Oct4, Nanog, CXCR4 as well as lung cancer stem cells surface marker CD44 and CD166. MiR-410 promotes stem cells-like properties such as proliferation, sphere formation, metastasis and chemoresistance. Moreover, Gsk3? is directly targeted and post-transcriptionally downregulated by miR-410. Also, the expression levels of miR-410 and Gsk3? may be correlated to clinicopathological differentiation in NSCLC tumor specimens. Additionally, we demonstrate miR-410 induces stemness through inhibiting Gsk3? but increasing Sox2, Oct4, Nanog and CXCR4, which binds to ?-catenin signaling. In conclusion, our findings identify the miR-410/Gsk3?/?-catenin signaling axis is a novel molecular circuit in inducing stemness of NSCLC. Twit Text FOAVip MiR-410 induces stemness by inhibiting Gsk3 but upregulating -catenin in non-small cells lung cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28076327 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28076327 #FOAvip English Wikipedia <ref>{{Cite pmid|28076327 }}</ref> MiR-410 induces stemness by inhibiting Gsk3? but upregulating ?-catenin in non-small cells lung cancer #MMPMID28076327 Ke X ; Yuan Y ; Guo C ; Yang Y ; Pu Q ; Hu X ; Tang K ; Luo X ; Jiang Q ; Su X ; Liu L ; Zhu W ; Wei Y Oncotarget 2017[Feb]; 8 (7 ): 11356-11371 PMID28076327 show ga Our previous research indicated miR-410 played a critical role in promoting the tumorigenesis and development of NSCLC (non-small cells lung cancer). MiR-410 has been recently reported to be crucial for development and differentiation of embryonic stem cells. But it remains elusive whether miR-410 stimulates the stemness of cancer until now. Herein, we identify miR-410 induces the stemness and is associated with the progression of NSCLC. We demonstrate miR-410 increases the levels of stem cells marker Sox2, Oct4, Nanog, CXCR4 as well as lung cancer stem cells surface marker CD44 and CD166. MiR-410 promotes stem cells-like properties such as proliferation, sphere formation, metastasis and chemoresistance. Moreover, Gsk3? is directly targeted and post-transcriptionally downregulated by miR-410. Also, the expression levels of miR-410 and Gsk3? may be correlated to clinicopathological differentiation in NSCLC tumor specimens. Additionally, we demonstrate miR-410 induces stemness through inhibiting Gsk3? but increasing Sox2, Oct4, Nanog and CXCR4, which binds to ?-catenin signaling. In conclusion, our findings identify the miR-410/Gsk3?/?-catenin signaling axis is a novel molecular circuit in inducing stemness of NSCLC. |Adult [MESH] |Aged [MESH] |Animals [MESH] |Blotting, Western [MESH] |Carcinoma, Non-Small-Cell Lung/genetics/*pathology [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Gene Expression Regulation, Neoplastic/*genetics [MESH] |Glycogen Synthase Kinase 3 beta/*biosynthesis/genetics [MESH] |Heterografts [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Lung Neoplasms/genetics/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Middle Aged [MESH] |Neoplastic Stem Cells/metabolism/pathology [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Signal Transduction/physiology [MESH] |Up-Regulation [MESH]MiR-410 induces stemness by inhibiting Gsk3? but upregulating ?-cateni(epmc).pdf DeepDyve Pubget Overpricing